Background: Chronic lumbar musculoskeletal pain (CLMSP) is a common comorbidity in post-stroke patients, thus functional clinical assessment is crucial to determine the need and type of rehabilitation program. Aim of the study: Identifying the burden of chronic lumbar musculoskeletal pain in post-stroke patients and assessing its impact on rehabilitation programs. Material and Methods: The analysis of 310 post-stroke patients revealed the presence of chronic lumbar musculoskeletal pain in 224 cases. All the patients were assessed through evaluation tools: Visual Analogue Scale for pain intensity, Roland-Morris Disability Questionnaire (RMDQ), Barthel Index (BI) for performance in activities of daily living before and after the rehabilitation program. Results: Chronic lumbar musculoskeletal pain was initially detected in 224 patients (72.2%). From those, before rehabilitation 3 patients (1.1%) presented mild pain, 131 patients (48.5%) moderate pain and 136 patients (50.3%) severe pain. After the rehabilitation program, the pain intensity decreased as follows: 34.1% of cases presented mild pain, 15.3% cases - moderate pain, and 2% of cases severe pain. Evaluation of disability due to lumbar pain assessed by RMDQ showed decreasing to the mean value from 15,000 to 10,000 points, but the BI averaging 79.4 increased to 86.2 after the rehabilitation program. Conclusion: Clinical-functional assessment is essential to determine the rehabilitation needs of post-stroke patients with CLMSP and to develop an individualized rehabilitation plan to improve their quality of life and ability to perform daily activities.