The use of whole milk substitute in feeding calves had a positive effect on the physiological state and metabolic processes in the animals' body. In the blood of calves of the experimental group, an increase in the concentration of hemoglobin by 1.9%, total protein by 3.9%, calcium by 3.8%, phosphorus by 2.3%, and a decrease in urea by 8.5% was found. Calves that consumed whole milk had the greatest productivity, and the-refore, their gross increase over the experience was higher in relation to group II animals by 3.0%.Feed costs for the production of 1 kg of experimental animal products amounted to 3.53 feed units in the first group and 3.59 in the second. Feeding whole milk substitute to calves aged 10-60 days (group II) led to a decrease in the cost of: a daily ration by 4.6%, 1 feed unit by 3.7%.When feeding a whole milk substitute, the cost of feed for obtaining an increase decreased by 1.9%, the cost of the increase by 1.8%.