This article presents the results of entomofaunistic investigations on the species Silphium perfoliatum, known as a fodder, honey, energy, medicinal and ornamental crop. Under the climatic conditions of the Republic of Moldova, S. perfoliatum, starting with the 3rd year of vegetation, enters the generative phase, blooms, bears fruit and produces viable seeds. It is characterized by a staggered and long flowering period (52-63 days) that occurs in July-October. The monitoring of the entomofauna has allowed the determination of the spectrum of insects attracted by the S. perfoliatum plants in the flowering stage. Ten species of insects included in 6 families and 4 orders were determined. The species of the Apidae family (Apis mellifera, Bombus terrestris, B. lapidarius), recognized as the main species of pollinating and honey insects, had the highest frequency on flowers.