Conţinutul numărului revistei |
Articolul precedent |
Articolul urmator |
![]() |
![]() ![]() ![]() |
Ultima descărcare din IBN: 2023-09-13 15:25 |
![]() CEBOTARI, Serghei, TUDORACHE, Igor, CIUBOTARU, Anatol, BOETHIG, Dietmar, SARIKOUCH, Samir, GOERLER, Adelheid, LICHTENBERG, Artur, CHEPTANARU, Eduard, BARNACIUC, Sergiu, CAZACU, Anatol, MALÎGA, Oxana, REPIN, Oleg, MANIUC, Liviu, BREYMANN, Thomas, HAVERICH, Axel. Use of fresh decellularized allografts for pulmonary valve replacement may reduce the reoperation rate in children and young adults: Early report. In: Circulation, 2011, vol. 124, supl. nr. 1, p. 0. ISSN 0009-7322. DOI: https://doi.org/10.1161/CIRCULATIONAHA.110.012161 |
EXPORT metadate: Google Scholar Crossref CERIF DataCite Dublin Core |
Circulation | ||||||
Volumul 124, Supliment nr. 1 / 2011 / ISSN 0009-7322 /ISSNe 1524-4539 | ||||||
|
||||||
DOI:https://doi.org/10.1161/CIRCULATIONAHA.110.012161 | ||||||
Pag. 0-0 | ||||||
|
||||||
![]() |
||||||
Rezumat | ||||||
Background-Degeneration of xenografts or homografts is a major cause for reoperation in young patients after pulmonary valve replacement. We present the early results of fresh decellularized pulmonary homografts (DPH) implantation compared with glutaraldehyde-fixed bovine jugular vein (BJV) and cryopreserved homografts (CH). Methods and Results-Thirty-eight patients with DPH in pulmonary position were consecutively evaluated during the follow-up (up to 5 years) including medical examination, echocardiography, and MRI. These patients were matched according to age and pathology and compared with BJV (n=38) and CH (n=38) recipients. In contrast to BJV and CH groups, echocardiography revealed no increase of transvalvular gradient, cusp thickening, or aneurysmatic dilatation in DPH patients. Over time, DPH valve annulus diameters converge toward normal z-values. Five-year freedom from explantation was 100% for DPH and 86±8% and 88±7% for BJV and CH conduits, respectively. Additionally, MRI investigations in 17 DPH patients with follow-up time >2 years were compared with MRI data of 20 BJV recipients. Both patient groups (DPH and BJV) were at comparable ages (mean, 12.7±6.1 versus 13.0±3.0 years) and have comparable follow-up time (3.7±1.0 versus 2.7±0.9 years). In DPH patients, the mean transvalvular gradient was significantly (P=0.001) lower (11 mm Hg) compared with the BJV group (23.2 mm Hg). Regurgitation fraction was 14±3% and 4±5% in DPH and BJV groups, respectively. In 3 DPH recipients, moderate regurgitation was documented after surgery and remained unchanged in follow-up. Conclusions-In contrast to conventional homografts and xenografts, decellularized fresh allograft valves showed improved freedom from explantation, provided low gradients in follow-up, and exhibited adaptive growth. |
||||||
Cuvinte-cheie alves, congenital, Heart Defects, surgery |
||||||
|
Google Scholar Export
<meta name="citation_title" content="Use of fresh decellularized allografts for pulmonary valve replacement may reduce the reoperation rate in children and young adults: Early report"> <meta name="citation_author" content="Cebotari Serghei"> <meta name="citation_author" content="Tudorache Igor"> <meta name="citation_author" content="Ciubotaru Anatol"> <meta name="citation_author" content="Boethig Dietmar"> <meta name="citation_author" content="Sarikouch Samir"> <meta name="citation_author" content="Goerler Adelheid"> <meta name="citation_author" content="Lichtenberg Artur"> <meta name="citation_author" content="Cheptanaru Eduard"> <meta name="citation_author" content="Barnaciuc Sergiu"> <meta name="citation_author" content="Cazacu Anatol"> <meta name="citation_author" content="Malîga Oxana"> <meta name="citation_author" content="Repin Oleg"> <meta name="citation_author" content="Maniuc Liviu"> <meta name="citation_author" content="Breymann Thomas"> <meta name="citation_author" content="Haverich Axel"> <meta name="citation_publication_date" content="2011/09/13"> <meta name="citation_journal_title" content="Circulation"> <meta name="citation_pdf_url" content="https://ibn.idsi.md/sites/default/files/imag_file/CIRCULATIONAHA.110.012161.pdf">