Synthesis and evaluation of antimicrobial activity of tetranorlabdane compounds bearing 1,3,4-thiadiazole units
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54.057:[547.913.5/.6+547.794.3] (1)
Production. Preparation. Isolation. Purification etc. (51)
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BLAJA, Svetlana, LUNGU, Lidia, CIOCARLAN, Alexandru, VORNICU, Nicoleta, ARICU, Aculina. Synthesis and evaluation of antimicrobial activity of tetranorlabdane compounds bearing 1,3,4-thiadiazole units. In: Chemistry Journal of Moldova, 2023, nr. 1(18), pp. 86-91. ISSN 1857-1727. DOI: https://doi.org/10.19261/cjm.2022.1026
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Chemistry Journal of Moldova
Numărul 1(18) / 2023 / ISSN 1857-1727 /ISSNe 2345-1688

Synthesis and evaluation of antimicrobial activity of tetranorlabdane compounds bearing 1,3,4-thiadiazole units

DOI:https://doi.org/10.19261/cjm.2022.1026
CZU: 54.057:[547.913.5/.6+547.794.3]

Pag. 86-91

Blaja Svetlana1, Lungu Lidia1, Ciocarlan Alexandru1, Vornicu Nicoleta2, Aricu Aculina1
 
1 Institute of Chemistry, MSU,
2 Metropolitan Center of Research TABOR, The Metropolitanate of Moldavia and Bukovina
 
 
Disponibil în IBN: 27 iunie 2023


Rezumat

Synthesis of novel tetranorlabdane compounds bearing 1,3,4-thiadiazole units and intermediary tetranorlabdane compounds with thiosemicarbazone fragment has been reported. The structures of the new synthesized compounds were confirmed using IR and 1H, 13C, and 15N NMR spectroscopy. The in vitro antifungal and antibacterial activities of the mentioned compounds have been evaluated. Results of this study have shown that the 1,3,4-thiadiazole-2-imine has excellent activity against tested strains of fungi and species of bacteria at minimum inhibitory concentration values of 0.125 and 2.5 μg/mL, respectively.

Cuvinte-cheie
( )-sclareolide, tetranorlabdane compound, 1, 3, 4-thiadiazole, thiosemicarbazone, Antimicrobial activity