The Global Innovation Index (GII) was conceived at INSEAD in 2006-2007 as a formal model to help show the degree to which countries currently respond to the challenge of innovation. Today, Innovation is not limited to the most advanced economies or to the high-technology sectors. Innovation has today become a global phenomenon, affecting all sectors of the economy. Feeding the world, while contributing to protecting the environment and providing quality and balanced nutrition to growing populations with different lifestyles and consumption patterns, remains a complex challenge. Innovation has a key role to play in addressing this challenge. In this paper, is given the Republic of Moldova’s ranking in 2011 – 2018, according to seven pillars: (1) institutions, (2) human capital and research, (3) infrastructure (ICT, energy, ecological sustainability), (4) market sophistication, (5) business sophistication, (6) Knowledge and technology outputs, (7) creative outputs. Ranking Republic of Moldova in GII 2011-2018 could help authorities not only to determine a country’s relative response capacity, but also gives a clearer picture of its strengths and deficiencies in respect to innovation related strategies, policies and practices.