Introduction. Suicidal behavior is a major health problem with serious social and economic consequences. Suicide is the 15th leading cause of death worldwide, while the global agestandardized suicide rate is estimated at 11.4 per 100,000 population and attempts are calculated to be 15-20 times more frequent than suicides. The repetition of suicide attempts strongly predicts subsequent attempts and eventually suicide. Material and methods. The publications on multiple suicide attempts available on PubMed were studied.Results. The most common risk factors for subsequent suicide attempts are previous ones. Among other factors that find the average age, unemployment, divorce, abandonment. About 90% of all suicides are associated with mental disorders. Current psychopathology and diagnosed mental disorders were found to strongly associate with multiple attempts. Patients with multiple attempts (two or more) in their history seem to have more severe depressive symptoms than those with a single attempt. Severe insomnia during the depressive episode, schizophrenic spectrum disorders, bipolar disorders, personality disorders, post-traumatic stress disorder, current recurrent psychotic syndrome, substance abuse are associated with an increased suicide risk. Repeated attempts and mood swings following the administration of antidepressants are frequently associated. Therefore, it is essential to follow the duration of the application of interventions for these people. Conclusions. The identification of risk factors can be used as a method of prevention and intervention. Studies are needed to address the impact of early screening for repetitive suicidal behavior and the importance of personalized suicide recurrence prevention programs.