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SM ISO690:2012 REVENCO, Ninel, CRACEA (DRUŞCA), Angela. Artrita juvenilă idiopatică (aji): interrelaţii corelative ale indicilor stresului oxidativ şi parametrii clinici. In: Buletin de Perinatologie, 2012, nr. 3, pp. 4-6. ISSN 1810-5289. |
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Buletin de Perinatologie | ||||||
Numărul 3 / 2012 / ISSN 1810-5289 | ||||||
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Pag. 4-6 | ||||||
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Rezumat | ||||||
Pathogenesis JIA is complex, constantly study. A separate role in perpetuating the infl ammatory response
is occupied by oxidative stress. If JIA, production of oxygen free radicals (OFR) exceeds the cellular antioxidant
capacity.
Material and methods. He conducted a randomized clinical trial that included 150 patients with JIA consecutive
hospitalized in Department of Rheumatology in 2008-2010. Clinical examination of patients with JIA was complex, studying
the peculiarities of articular syndrome (number of joints - NAD and swollen - NAT, global assessment of disease
by a doctor – GADM and patient - GADP, visual analogue pain scale - VAPS) and disease activity assessed by activity
index DAS28 complex in 150 patients with JIA. In 90 patients with JIA indices rose prooxidant system (total prooxidant
activity - TPA, dialdehyde malone - DAM) and antioxidant system indices (total antioxidant activity - TAA, superoxiddismutaza
- SOD, catalase, ceruloplasmin). Pearson correlation coeffi cient (r) from 0 to 0,3 indicates little correlation,
0,3 to 0,7 - average correlation, 0,7 to 1,0 - high correlation, as the reliability of the parameters studied.
Results obtained. In patients with JIA there were found strong and medium direct correlative interrelations between
clinical parameters. There were determined direct weak and medium correlative interrelations between clinical
parameters pro-oxidant indices (APT and DAM). Between pro-oxidant indices (APT and DAM) there was revealed a
medium direct correlation. Low and medium indirect correlative interrelations were found between clinical parameters
and antioxidant indices (SOD and catalase). There were observed weak and medium direct correlative interrelations
between the antioxidant indices (AAT, SOD, catalase and ceruloplasmin). There were found weak, medium and strong
direct correlative interrelations between the pro-oxidant and antioxidant indices.
Conclusions. In patients with JIA were determined direct weak and medium correlative interrelations between clinical
parameters pro-oxidant indices (APT and DAM). Low and medium indirect correlative interrelations were found
between clinical parameters and antioxidant indices (SOD and catalase). |
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Cuvinte-cheie Juvenile idiopathic arthritis, oxidative stress, correlation indices |
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