In this article we consider the class QS of all non-degenerate quadratic systems. A quadratic polynomial differential system can be identified with a single point of ℝ¹² through its coefficients. In this paper using the algebraic invariant theory we provided necessary and sufficient conditions for a system in QS to have at least one invariant hyperbola in terms of its coefficients. We also considered the number and multiplicity of such hyperbolas. We give here the global bifurcation diagram of the class QS of systems with invariant hyperbolas. The bifurcation diagram is done in the 12-dimensional space of parameters and it is expressed in terms of polynomial invariants. The results can therefore be applied for any family of quadratic systems in this class, given in any normal form.