This paper presents the results of the study of the epidemiological situation of rabies in the last 10 years on the territory of the Republic of Moldova. It has been found that the most susceptible animal species to rabies virus are cattle (358 cases), dogs (304 cases), foxes (186 cases) and cats (150 cases), which constitute 91.14% of the total number of cases recorded in animals in the last 10 years. The fox is the rabies-reservoir species and the main vector of its spread in wild animal populations. In the livestock sector, cattle are the most affected and constitute 32.69%. Data obtained from the study show that rabies is developing sporadically. In the population of wild animals other than foxes, cases of the disease are not dependent on the existence of infected foxes in that area. It has also been found that there is no significant correlation of rabies in fox and dogs, fox and cattle, or dogs and cattle. At the same time, there has been found a correlation between the number of fox units and rabies cases and a cyclicity of rabies cases every 4 years (2012-2015 and 2016-2019). The influence of thermal variations on the incidence of rabies in living biodiversity has specific oscillating effects according to the years of study, with multiple divergences, which require a well-founded argument, based on the existing importance of the problem approached through high-performance scientific research.