Introduction Polytrauma is a serious life-threatening injury that leads to death, without an active and intensive approach to diagnosis, can result in long-term disability. The assessment, management, and prognosis of polytraumas differ significantly from isolated injuries. Rehabilitation is essential for patients with polytrauma and can help a person reintegrate into social life. Materials and methods: We present the case of a 32-year –old woman with polytrauma, after a car accident. A post-acute home-based approach rehabilitation program was developed. Results: The patient has transported to the Institute of Emergency Medicine,after being hit by a car, unconscious, and diagnosed: Polytrauma - craniocerebral trauma; Severe concussion; Severe subarachnoid hemorrhage; Multiple fractures of the left temporal and frontal bone with passage into the middle temporal fossa; Fracture of the cranial base in the middle cranial fossa on the left; Traumatic cerebral edema; Contusion wound in the frontal region; Fracture of the left pubic branch and the sacrum; Cranial hypertension; Zygomatic bone fracture; Fracture of the orbit on the left. she received inpatient treatment for 14 days: 7 in intensive care and 7 in the neurosurgery department. At home, a multifunctional bed was prepared and rehabilitation therapy was initiated by the following methods: active and passive physiotherapy, electrotherapy, massage, occupational therapy, TENS, electromagnetic field, and paraffin applications. After the home-based program, the patient was referred to community rehabilitation services showing good outcomes with minimal functional deficits at 6 months. Conclusion: A home-based approach program with early initiation can enhance rehabilitation for persons with polytrauma.