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Ultima descărcare din IBN: 2020-05-06 22:59 |
SM ISO690:2012 CHIRIAC, Tatiana. Proprietăţile antihipertensive ale benzituronului. In: Curierul Medical, 2012, nr. 4(328), pp. 41-45. ISSN 1875-0666. |
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Curierul Medical | ||||||
Numărul 4(328) / 2012 / ISSN 1875-0666 | ||||||
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Pag. 41-45 | ||||||
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Benzituron or S-benzylisothiourea chloride is exposed to a new range of hypotensive substances, isothiourea derivatives, it is able to reduce and stabilize the level of the arterial pressure. The benzituron solution, in a dosage of 2 mg/kg, shows a noticeable decrease in hypotension and antihypertension that lasts 4-5 hours. Benzituron can manifest hypotensive action in arterial hypertension. This hypotension is caused by phenylefrine, with increased efficacy when taken with benzituron hypotension, which shows that alpha-adrenoreceptors are not occupied and can react with alpha-adrenomimetic drug. Ephedrine induced hypertension also is decreased by benyituron, even below the initial level. Also, repeated administration of ephedrine doesn’t influence vasodilating action of benzituron. Our research showed that one-time administration of angiotensine-II increased BP (blood pressure), while a subsequent injection of benzituron decreased it. Angiotensine-II, when administered 60 min after benzituron, reestablished the level of blood pressure. |
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Cuvinte-cheie isothiourea derivative, antihypertensive effect, benzituron, blood pressure |
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