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SM ISO690:2012 NASTAS, Igor. Adjunctive aspirin vs estradiol in patients with schizophrenia. In: Sănătate mintală într-o lume plină de provocări: Congresului Internațional al Societății Psihiatrilor, Narcologilor, Psihoterapeuților și Psihologilor Clinicieni, 23-26 iunie 2021, Chişinău. Chișinău, Republica Moldova: FPC „PRIMEX-Com” SRL, 2021, Ediția a II-a, p. 73. ISBN 978-9975-3493-7-6. |
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Sănătate mintală într-o lume plină de provocări Ediția a II-a, 2021 |
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Congresul " Sănătate mintală într-o lume plină de provocări" Chişinău, Moldova, 23-26 iunie 2021 | ||||||
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Pag. 73-73 | ||||||
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Importance: Several lines of evidence suggest that adjunctive therapies influences the course of schizophrenia. Design and intervention: We conducted two 16-week double-blind randomized placebo-controlled RCTs of adjunctive 1000 mg aspirin vs placebo in schizophrenia. Study 1 included 200 patients, with Positive and Negative Syndrome Scale (PANSS) total score as the primary outcome. Study 2 included 160 patients with C-reactive protein (CRP) >1 mg/L at baseline. The primary outcome was PANSS-positive score. The other 8-week randomized, placebo-controlled trial among 200 premenopausal women aged 19 to 46 years with schizophrenia or schizoaffective disorder as defined by the DSM-5 who received a 200-μg estradiol patch or placebo patch changed twice a week added to their antipsychotic treatment. Results and conclusions: While there is a sound theoretical basis for an anti-inflammatory hypothesis in schizophrenia, we conclude that our studies and meta-analysis failed to find a statistically significant improvement of adjunctive aspirin therapy in comparison to placebo in schizophrenia. The results in trial with estradiol suggest that transdermal estradiol is an effective add-on treatment for women of childbearing age with schizophrenia and extend it, finding improvements in negative symptoms and finding that the effect could be specific to those older than 38 years. |
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Cuvinte-cheie schizophrenia, adjunctive treatment, aspirin, estradiol |
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