Articolul precedent |
Articolul urmator |
317 0 |
SM ISO690:2012 GURANDA, Diana, CIOBANU, Cristina, CIOBANU, Nicolae, SOLONARI, Rodica. Optimization of magistral semi-solid forms used in urogenital diseases. In: Cercetarea în biomedicină și sănătate: calitate, excelență și performanță, Ed. 1, 20-22 octombrie 2021, Chişinău. Chișinău, Republica Moldova: 2021, p. 447. ISBN 978-9975-82-223-7 (PDF).. |
EXPORT metadate: Google Scholar Crossref CERIF DataCite Dublin Core |
Cercetarea în biomedicină și sănătate: calitate, excelență și performanță 2021 | ||||||
Conferința "Cercetarea în biomedicină și sănătate: calitate, excelență și performanță" 1, Chişinău, Moldova, 20-22 octombrie 2021 | ||||||
|
||||||
Pag. 447-447 | ||||||
|
||||||
Descarcă PDF | ||||||
Rezumat | ||||||
Background. Urinary tract infections are the most common urogenital diseases, with an increased incidence in women and the elderly. Urogenital infections are caused by Gram-negative germs, in which E. coli predominates with a share of 85-90%. Objective of the study. Research of the optimized preparation technology of magistral suppositories by comparative evaluation of their quality parameters. Material and Methods. Suppositories were prepared based on hydrophobic and hydrophilic excipients, the dosing was performed spectrophotometric UV-VI Sona Perkin Elmer-40 spectrophotometer, solvents and reagents had the degree of purity" pure for analysis "and" chemically pure". Results. In the "Vasile Procopisin" University Pharmaceutical Center, suppositories were prepared with furagin, dimexid, anestesin, methyleneblue on cocoa butter excipient (manual modeling method) and on hydrophilic excipients PEG 400:PEG 4000 (by melting and molding method). Both types of suppositories were subjected to quality tests, including their stability at temperature, humidity, UV irradiation, the quantitative determinations were performed by UV-VIS spectrophotometric method. On the spectra there were no maxima corresponding to the degradation products that overlap with the maxima of the active substances, the UV stress does not cause a major degradation of the furagin. Conclusion. Suppositories with furagin and other active components were prepared by technological methods. The results obtained performing the UV-VIS spectrophotometric analysis were subsequently used for the stability studies of there searched forms. |
||||||
Cuvinte-cheie suppositories, furagin, stability studies, supozitoare, furagină, studii de stabilitate |
||||||
|