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SM ISO690:2012 DUMITRAS, Ana-Maria, BROCOVSCHII, Victoria, TOMA, Cristina, CEMÎRTAN, Svetlana. Molecular diagnostics in hymoneptera venom allergy. In: Cercetarea în biomedicină și sănătate: calitate, excelență și performanță, Ed. 1, 20-22 octombrie 2021, Chişinău. Chișinău, Republica Moldova: 2021, p. 149. ISBN 978-9975-82-223-7 (PDF).. |
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Cercetarea în biomedicină și sănătate: calitate, excelență și performanță 2021 | ||||||
Conferința "Cercetarea în biomedicină și sănătate: calitate, excelență și performanță" 1, Chişinău, Moldova, 20-22 octombrie 2021 | ||||||
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Pag. 149-149 | ||||||
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Rezumat | ||||||
Background. Venom allergy is one of the most frequent triggers of severe anaphylactic reactions in adults. Up to 28.7 % of the adult population have a sensitization to Hymenoptera venom, and the prevalence of systemic severe reactions among adults ranges between 0.3 and 7.5 %. Objective of the study. To highlight the diagnostic features, including molecular approach of the sensitization to hymenoptera venom, in patients of Republic of Moldova. Material and Methods. The study included 100 patients aged 1 to 69 years, who performed the multiplex allergy test ALEX, specific IgE (sIgE) against allergen extracts and molecular components of hymenoptera. The data was processed through the Microsoft Excel. Results. About 40% of surveyed patients showed at least one sensitization to hymenoptera venom (bees, vespides and ants). Female accounted for 51% in the study group. The highest rate of hymenoptera sensitisation (28%) was recorded in the age group 30-39 years. Particularly sensitization to Western bee extract has been showed in 9 cases (22,5%), and to the major allergenic molecules Api m 1- in 7 cases (17,5%) and Api m 10 - 13 patients (32,5%). Specific markers of sensitization to wasp venom were: Ves v1 - 1 case (2,5%) and Ves v5- 19 cases (47,5%). Conclusion. Hymenoptera sensitivity is common and can be potentially fatal in particular cases. The assessment of sensitization to major molecular components of hymenoptera acts as a prognostic marker for severe reactions as well as guidance in allergen specific immunotherapy. |
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Cuvinte-cheie venom, immunoglobulin E, Hymenoptera, sensitization, venin, imunoglobuline E, himenoptere, sensibilizare |
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