Articolul precedent |
Articolul urmator |
349 0 |
SM ISO690:2012 SPÎNOSU, Galina, BACHINSKY, N.G.. Assessing the harmlessness of monarda medical preparations by determining acute toxicity. In: Cercetarea în biomedicină și sănătate: calitate, excelență și performanță, Ed. 1, 20-22 octombrie 2021, Chişinău. Chișinău, Republica Moldova: 2021, p. 36. ISBN 978-9975-82-223-7 (PDF).. |
EXPORT metadate: Google Scholar Crossref CERIF DataCite Dublin Core |
Cercetarea în biomedicină și sănătate: calitate, excelență și performanță 2021 | ||||||
Conferința "Cercetarea în biomedicină și sănătate: calitate, excelență și performanță" 1, Chişinău, Moldova, 20-22 octombrie 2021 | ||||||
|
||||||
Pag. 36-36 | ||||||
|
||||||
Descarcă PDF | ||||||
Rezumat | ||||||
Background. Bacterial and fungal infections present a public health problem worldwide due to the increased incidence of pathologies, the number of agents involved, as well as the increase in resistance to existing medicine. Objective of the study. Assessing the harmlessness of monarda medical preparations by determining acute toxicity. Material and Methods. The liquid extract was administered in a single dose of 2 g / kg by oral gavage using 5 rats (limit test). Monarda volatile oil and volatile oil of monarda with timochinon have been administered by oral gavage doses of each 2000, 1000, 500 and 250 mg / kg (by 10 mice group of both sexes ). The lethality was assessed on the 14th day with LD50 calculation by probit-analysis method. Results. After oral administration of monarda liquid extract at a dose of 2 g / kg in rats and mice, no deaths were reported. The observed shows that the LD50 of the monarda liquid extract exceeds 2 g / kg in both animal species. LD 50 of the essential oil of monarda is 334.7 mg / kg, and the essential oil of monarda with timochinon – is 916 , 2 mg / kg. Conclusion. On the basis of LD 50 the liquid extract from monarda can be considered not toxic, data that suggest the necessity of researching chronic toxicity and antibacterial propertie |
||||||
Cuvinte-cheie Keywords: Monarda, Liquid extracts, essential oil, acute toxicity, Monarda, extracte lichide, uleiuri esenţiale, toxicitatea acută |
||||||
|