Objectives: establishing impact of vascular risk factors, particularly migraine on severity of Parkinson's disease. Methods: Analysis included 29 consecutive PD patients from Moldovan cohort (20.80009.8007.39), mean age 63.3±8.1 yo, mean disease duration 48.9±12.9 mo., mean disease onset age of 59.0±8.7 y. Motor assessment (UPDRS II scale, Tremor Score, Akinetic-rigid Score), quality of life impairment (PDQ39), cognitive performance (MoCA) were conducted. Presence of vascular risk factors (FRV), including migraine (Mg), QRISK3 scores and relative cardiovascular risk were determined. Results: Twenty-five (86.2%) of total PD patients had VRF. Migraine present in 41% of them. PD+VRF was associated with higher scores of disease severity: UPDRS II 46.73±11.75 (vs. 42.75±23.71), TrScore 0.94±0.56 (vs. 0.88±0.33), ARScore 0.82±0.53 (vs. 0.70±0.12), higher PDQ39 52.78±27, 81 (vs. 41.25±20.16) and lower cognitive MoCA scores 21.75±4.07 (vs. 22.60±3.29), not reaching statistical significance. PD+Mg had higher PDQ39 index: 55.00±31.12 (vs. 48.88±24.35) and lower MoCA cognitive scores - 21.48±4.20 (vs. 22.09±3.90), no statistically significant difference. PD+Mg patients had significantly higher relative cardiovascular risk scores - 2.80±6.84 (vs. 1.53±0.66, p = 0.02). Conclusions: Vascular risk factors, if present in PD patients, may predict a worse motor and cognitive performance. Migraine presence significantly increases the patients cardiovascular risk.