The basic criteria of drinking water quality, which are formulated in the middle of the twentieth century, are: drinking water should be safe in the epidemiological relation, should be safe under chemical contents and should have acceptable organoleptic properties. Normative documents in the field of drinking water quality worldwide are based on these requirements. Guidelines on drinking water quality assurance (WHO, 1994) are the main international document regulating the requirements to drinking water quality. A lot of standards (standard techniques of ЕРА and EU), regulating the contents in water of many xenobiotics - pesticides, PAC, phenols, dioxins, heavy metals and volatile organic substances are developed In the USA and Europe. Similar standards exist in Ukraine. Development of hygienic specifications for various ecotoxicants in drinking water, superficial and underground water sources of drinking purpose are constantly carried out in Ukraine considering special importance for population health status of quality of drinking water. From arsenal of analytical water chemistry with more than 150 techniques the most effective and reliable are the techniques based on chromatography (gas liquid, highly performance liquid, thin layered), spectroscopy and the electrochemistry, covering all spectrum of anthropogenous water pollutants. One of leading places at definition of drinking water quality is occupied by analytical methods of quantitative definition of residual quantities of pesticides in water. In this connection for determination in water of pesticides microquantities concerning to various classes of organic substances methods of the analysis directed on reduction of adverse influences of toxicants on the human and environment are developed in L.I.Medved’s Institute of Ecohygiene and Toxicology. During the development of methods of pesticides analysis in water with the purpose of their quantitative extraction the mentioned below is used: - traditional liquid extraction, based on donor-acceptor interaction. Solvents of different classes were used as extragents for pesticides containing polar functional groups. Factors of pesticides distribution in various systems are determined with the purpose of choosing of optimum variant of extragent, his quantity and frequency of extraction; - solid phase extraction with concentrating on cartridges with sorbents, cation exchange and anion exchange pitches. Processes of pesticides sorption and desorption are investigated, sorption capacity is calculated; - the static variant of vapor-phase extraction is used for volatile organic substances or destruction products of not volatile substances. The received results are generalized and included in basis of measurements techniques for determination of pesticides residues in water, providing the state sanitary and epidemiological supervision on application of pesticides in Ukraine.