Conţinutul numărului revistei |
Articolul precedent |
Articolul urmator |
![]() |
![]() ![]() |
Ultima descărcare din IBN: 2022-08-03 14:00 |
Căutarea după subiecte similare conform CZU |
616.36-006-02:616.36-002.2 (1) |
Pathology of the digestive system. Complaints of the alimentary canal (1819) |
![]() . Conceptul de cancer precoce la pacienții cu hepatopatie cronică virală B, C şi Delta. In: Buletinul Academiei de Ştiinţe a Moldovei. Ştiinţe Medicale, 2020, nr. 4(68), pp. 136-145. ISSN 1857-0011. |
EXPORT metadate: Google Scholar Crossref CERIF DataCite Dublin Core |
Buletinul Academiei de Ştiinţe a Moldovei. Ştiinţe Medicale | ||||||
Numărul 4(68) / 2020 / ISSN 1857-0011 | ||||||
|
||||||
CZU: 616.36-006-02:616.36-002.2 | ||||||
Pag. 136-145 | ||||||
|
||||||
![]() |
||||||
Rezumat | ||||||
Early hepatocellular carcinoma was defined as a well-differentiated cancer without substantial destruction of the pre-existing hepatic framework. Recent imaging techniques facilitate early detection in patients at risk for regular monitoring of chronic viral hepatitis or liver cirrhosis. Thus, we performed a prospective / retrospective study of hepatocellular carcinoma screening in patients with viral hepatitis B, C and Delta, and this review shows the clinical significance of early detection of HCC with an impact on patient survival. Material and methods: The diagnosis of hepatocellular carcinoma was based on the presence of a liver tumor obtained by imaging, and confirmed histopathologically (in some cases, especially early), on the clinical context, nuanced by the presence of a chronic liver disease (hepatitis or liver cirrhosis), on the assessment of markers serum levels of viral liver infections (B, C, D) and alpha-fetoprotein levels> 400 ng / ml). Data on socio-demographic status, clinical symptoms, clinical biochemistry, haematology, serological data on the three main viruses responsible for persistent liver infections (hepatitis B, C and Delta virus), lifestyle risk factors, infectious risk factors , histological examination of non-tumor liver, tumor number and diameter, lymph node involvement, metastases, duration of treatment and survival time were collected from medical records and stored in a database. Results: Patients with hepatocellular carcinoma were detected in 80% of cases with chronic viral infection B with or without Delta and C antigen, with a mean age of 59.2 ± 10.1 years, and male patients tended to be younger , than women (58.0 ± 10.3 vs 61.9 ± 9.1, P = 0.070). Patients with hepatocellular carcinoma associated with HDV showed a patient profile 6 years younger than patients infected with HCV and HBV (monoinfection) (54.0 ± 8.3 vs 60.5 ± 10.1 years, P = 0, 0041) and with a universal cirrhotic liver vs other patients (95.8 vs 79.2%, OR = 5.96, 95% CI: 0.87-256.95, P = 0.074). Conclusion: In Republic of Moldova hepatocellular carcinoma is about 80% of cases caused by one of the hepatitis infections: HBV, HCV, VHD. And the HCC specific mortality can be reduced by screening and prompt surveillance of patients with chronic viral liver disease. |
||||||
Cuvinte-cheie hepatocellular carcinoma, viral hepatitis, HBV, HCV, HDV, гепатоцеллюлярная карцинома, вирусный гепатит, HBV, HCV, HDV |
||||||
|
Cerif XML Export
<?xml version='1.0' encoding='utf-8'?> <CERIF xmlns='urn:xmlns:org:eurocris:cerif-1.5-1' xsi:schemaLocation='urn:xmlns:org:eurocris:cerif-1.5-1 http://www.eurocris.org/Uploads/Web%20pages/CERIF-1.5/CERIF_1.5_1.xsd' xmlns:xsi='http://www.w3.org/2001/XMLSchema-instance' release='1.5' date='2012-10-07' sourceDatabase='Output Profile'> <cfResPubl> <cfResPublId>ibn-ResPubl-132192</cfResPublId> <cfResPublDate>2020-12-30</cfResPublDate> <cfVol>68</cfVol> <cfIssue>4</cfIssue> <cfStartPage>136</cfStartPage> <cfISSN>1857-0011</cfISSN> <cfURI>https://ibn.idsi.md/ro/vizualizare_articol/132192</cfURI> <cfTitle cfLangCode='RO' cfTrans='o'>Conceptul de cancer precoce la pacienții cu hepatopatie cronică virală B, C şi Delta</cfTitle> <cfKeyw cfLangCode='RO' cfTrans='o'>hepatocellular carcinoma; viral hepatitis; HBV; HCV; HDV; гепатоцеллюлярная карцинома; вирусный гепатит; HBV; HCV; HDV</cfKeyw> <cfAbstr cfLangCode='EN' cfTrans='o'><p>Early hepatocellular carcinoma was defined as a well-differentiated cancer without substantial destruction of the pre-existing hepatic framework. Recent imaging techniques facilitate early detection in patients at risk for regular monitoring of chronic viral hepatitis or liver cirrhosis. Thus, we performed a prospective / retrospective study of hepatocellular carcinoma screening in patients with viral hepatitis B, C and Delta, and this review shows the clinical significance of early detection of HCC with an impact on patient survival. Material and methods: The diagnosis of hepatocellular carcinoma was based on the presence of a liver tumor obtained by imaging, and confirmed histopathologically (in some cases, especially early), on the clinical context, nuanced by the presence of a chronic liver disease (hepatitis or liver cirrhosis), on the assessment of markers serum levels of viral liver infections (B, C, D) and alpha-fetoprotein levels> 400 ng / ml). Data on socio-demographic status, clinical symptoms, clinical biochemistry, haematology, serological data on the three main viruses responsible for persistent liver infections (hepatitis B, C and Delta virus), lifestyle risk factors, infectious risk factors , histological examination of non-tumor liver, tumor number and diameter, lymph node involvement, metastases, duration of treatment and survival time were collected from medical records and stored in a database. Results: Patients with hepatocellular carcinoma were detected in 80% of cases with chronic viral infection B with or without Delta and C antigen, with a mean age of 59.2 ± 10.1 years, and male patients tended to be younger , than women (58.0 ± 10.3 vs 61.9 ± 9.1, P = 0.070). Patients with hepatocellular carcinoma associated with HDV showed a patient profile 6 years younger than patients infected with HCV and HBV (monoinfection) (54.0 ± 8.3 vs 60.5 ± 10.1 years, P = 0, 0041) and with a universal cirrhotic liver vs other patients (95.8 vs 79.2%, OR = 5.96, 95% CI: 0.87-256.95, P = 0.074). Conclusion: In Republic of Moldova hepatocellular carcinoma is about 80% of cases caused by one of the hepatitis infections: HBV, HCV, VHD. And the HCC specific mortality can be reduced by screening and prompt surveillance of patients with chronic viral liver disease.</p></cfAbstr> <cfAbstr cfLangCode='RU' cfTrans='o'><p>Ранняя гепатоцеллюлярная карцинома была определена как хорошо дифференцированный рак без существенного разрушения ранее существовавшего каркаса печени. Современные методы визуализации облегчают раннее выявление у пациентов из группы риска для регулярного мониторинга хронического вирусного гепатита или цирроза печени. Таким образом, мы провели проспективное / ретроспективное исследование скрининга гепатоцеллюлярной карциномы у пациентов с вирусными гепатитами B, C и Delta, и этот обзор показывает клиническую значимость раннего выявления ГЦК с влиянием на выживаемость пациентов. Материал и методы: Диагноз гепатоцеллюлярной карциномы основывался на наличии опухоли печени, полученной с помощью визуализации, и подтвержден гистопатологически (в некоторых случаях, особенно на ранних стадиях), в клиническом контексте с нюансами наличия хронического заболевания печени (гепатит). или цирроз печени), при оценке сывороточных маркеров вирусных инфекций печени (B, C, D) и уровней альфа-фетопротеина> 400 нг / мл). Данные о социально-демографическом статусе, клинических симптомах, клинической биохимии, гематологии, серологические данные о VHB, VHC, VHD, факторы риска образа жизни, факторы риска инфекций, гистологическое исследование опухоль печени, количество и диаметр опухоли, поражение лимфатических узлов, метастазы, продолжительность лечения и время выживания - были собраны из медицинских записей и сохранены в базе данных. Результаты. Пациенты с ГЦК выявлялись в 80% случаев с хронической вирусной инфекцией B с антигеном Delta и C или без него, со средним возрастом 59,2 ± 10,1 года, причем пациенты мужского пола были моложе женщин (58,0 ± 10,3). по сравнению с 61,9 ± 9,1, P = 0,070). Пациенты с ГЦК, ассоциированной с HDV, имели профиль пациентов на 6 лет моложе, чем пациенты, инфицированные HCV и HBV (моноинфекция) (54,0 ± 8,3 против 60,5 ± 10,1 года, P = 0,0041), и с универсальным циррозом печени по сравнению с другими пациентами ( 95,8 против 79,2%, OR = 5,96, 95% CI: 0,87-256,95, P = 0,074). Заключение: В Республике Молдова ГЦК составляет около 80% случаев, вызванных одной из инфекций гепатита: HBV, HCV, VHD. Смертность от ГЦК может быть снижена путем скрининга и оперативного наблюдения за пациентами с хроническим вирусным заболеванием печени.</p></cfAbstr> <cfResPubl_Class> <cfClassId>eda2d9e9-34c5-11e1-b86c-0800200c9a66</cfClassId> <cfClassSchemeId>759af938-34ae-11e1-b86c-0800200c9a66</cfClassSchemeId> <cfStartDate>2020-12-30T24:00:00</cfStartDate> </cfResPubl_Class> <cfResPubl_Class> <cfClassId>e601872f-4b7e-4d88-929f-7df027b226c9</cfClassId> <cfClassSchemeId>40e90e2f-446d-460a-98e5-5dce57550c48</cfClassSchemeId> <cfStartDate>2020-12-30T24:00:00</cfStartDate> </cfResPubl_Class> <cfPers_ResPubl> <cfPersId>ibn-person-12092</cfPersId> <cfClassId>49815870-1cfe-11e1-8bc2-0800200c9a66</cfClassId> <cfClassSchemeId>b7135ad0-1d00-11e1-8bc2-0800200c9a66</cfClassSchemeId> <cfStartDate>2020-12-30T24:00:00</cfStartDate> </cfPers_ResPubl> </cfResPubl> <cfPers> <cfPersId>ibn-Pers-12092</cfPersId> <cfPersName_Pers> <cfPersNameId>ibn-PersName-12092-2</cfPersNameId> <cfClassId>55f90543-d631-42eb-8d47-d8d9266cbb26</cfClassId> <cfClassSchemeId>7375609d-cfa6-45ce-a803-75de69abe21f</cfClassSchemeId> <cfStartDate>2020-12-30T24:00:00</cfStartDate> <cfFamilyNames>Цуркану</cfFamilyNames> <cfFirstNames>Адела</cfFirstNames> </cfPersName_Pers> </cfPers> </CERIF>