| Conţinutul numărului revistei |
| Articolul precedent |
| Articolul urmator |
 433 0 |
 SM ISO690:2012SANTOS, Victor Santana, GOLETTI, Delia, NOI, Autori, KRUDU, V.. Acute phase proteins and IP-10 as triage tests for the diagnosis of tuberculosis: systematic review and meta-analysis. In: Clinical Microbiology and Infection, 2019, nr. 2(25), pp. 169-177. ISSN 1198-743X. DOI: https://doi.org/10.1016/j.cmi.2018.07.017 |
| EXPORT metadate: Google Scholar Crossref CERIF DataCite Dublin Core |
  Clinical Microbiology and Infection |
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| Numărul 2(25) / 2019 / ISSN 1198-743X /ISSNe 1469-0691 | |
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| DOI:https://doi.org/10.1016/j.cmi.2018.07.017 | |
| Pag. 169-177 | |
| Rezumat | |
Objectives: We examined the data reported in studies for diagnostic purposes and to discuss whether their intended use could be extended to triage, as rule-in or rule-out tests to select individuals who should undergo further confirmatory tests. Methods: We searched Scopus, PubMed and Web of Science with the terms ‘acute phase proteins,’ ‘IP-10,’ ‘tuberculosis,’ 'screening’ and ‘diagnosis,’ extracted the sensitivity and specificity of the biomarkers and explored methodologic differences to explain performance variations. Summary estimates were calculated using random-effects models for overall pooled accuracy. The hierarchical summary receiver operating characteristic model was used for meta-analysis. Results: We identified 14, four and one studies for C-reactive protein (CRP), interferon γ–induced protein 10 (IP-10) and alpha-1-acid glycoprotein (AGP). The pooled CRP sensitivity/specificity (95% confidence interval) was 89% (80–96) and 57% (36–65). Sensitivity/specificity were higher in high-tuberculosis-burden countries (90%/64%), HIV-infected individuals (91%/61%) and community-based studies (90%/62%). IP-10 sensitivity/specificity in TB vs. non-TB studies was 85%/63% and in TB and HIV coinfected vs. other lung conditions 94%/21%. However, IP-10 studies included diverse populations and a high risk of bias, resulting in very low-quality evidence. AGP had 86%/93% sensitivity/specificity. Conclusions: Few studies have evaluated CRP, IP-10 and AGP for the triage of symptomatic patients. Their high sensitivity and moderate specificity warrant further prospective studies exploring whether their combined use could optimize performance. |
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| Cuvinte-cheie acute phase proteins, IP-10screening, systematic review, tuberculosis |
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Dublin Core Export
<?xml version='1.0' encoding='utf-8'?> <oai_dc:dc xmlns:dc='http://purl.org/dc/elements/1.1/' xmlns:oai_dc='http://www.openarchives.org/OAI/2.0/oai_dc/' xmlns:xsi='http://www.w3.org/2001/XMLSchema-instance' xsi:schemaLocation='http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd'> <dc:creator>Santos, V.</dc:creator> <dc:creator>Goletti, D.</dc:creator> <dc:creator>Noi, A.</dc:creator> <dc:creator>Crudu, V.N.</dc:creator> <dc:date>2019-02-24</dc:date> <dc:description xml:lang='en'><p>Objectives: We examined the data reported in studies for diagnostic purposes and to discuss whether their intended use could be extended to triage, as rule-in or rule-out tests to select individuals who should undergo further confirmatory tests. Methods: We searched Scopus, PubMed and Web of Science with the terms ‘acute phase proteins,’ ‘IP-10,’ ‘tuberculosis,’ 'screening’ and ‘diagnosis,’ extracted the sensitivity and specificity of the biomarkers and explored methodologic differences to explain performance variations. Summary estimates were calculated using random-effects models for overall pooled accuracy. The hierarchical summary receiver operating characteristic model was used for meta-analysis. Results: We identified 14, four and one studies for C-reactive protein (CRP), interferon γ–induced protein 10 (IP-10) and alpha-1-acid glycoprotein (AGP). The pooled CRP sensitivity/specificity (95% confidence interval) was 89% (80–96) and 57% (36–65). Sensitivity/specificity were higher in high-tuberculosis-burden countries (90%/64%), HIV-infected individuals (91%/61%) and community-based studies (90%/62%). IP-10 sensitivity/specificity in TB vs. non-TB studies was 85%/63% and in TB and HIV coinfected vs. other lung conditions 94%/21%. However, IP-10 studies included diverse populations and a high risk of bias, resulting in very low-quality evidence. AGP had 86%/93% sensitivity/specificity. Conclusions: Few studies have evaluated CRP, IP-10 and AGP for the triage of symptomatic patients. Their high sensitivity and moderate specificity warrant further prospective studies exploring whether their combined use could optimize performance. </p></dc:description> <dc:identifier>10.1016/j.cmi.2018.07.017</dc:identifier> <dc:source>Clinical Microbiology and Infection 25 (2) 169-177</dc:source> <dc:subject>acute phase proteins</dc:subject> <dc:subject>IP-10screening</dc:subject> <dc:subject>systematic review</dc:subject> <dc:subject>tuberculosis</dc:subject> <dc:title>Acute phase proteins and IP-10 as triage tests for the diagnosis of tuberculosis: systematic review and meta-analysis</dc:title> <dc:type>info:eu-repo/semantics/article</dc:type> </oai_dc:dc>
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