Introduction. Indications for the use of platelet-rich plasma (PRP) in modern medicine are expanding every year, thanks to the high success of this technology. This article provides answers to questions: the essence of the method and its safety.  Aim of the study. To analyze the efficacy of using platelet-enriched plasma in surgical treatment (sinus lifting, dental extraction, implantology), as well as in the treatment of the diseases associated to periodontal tissues (gingivitis, periodontitis) of the oral cavity.  Material and methods. In accordance with the proposed purpose and objectives, we analyzed medical records and photographic data base of 20 patients and the sulcus bleeding index (SBI) before and after the treatment, this way we demonstrated the ability of healing and tissues regenerations. The method represents application the injection form of plasma which is obtained from the patients own blood and containing platelets which is accomplished by centrifugation using tubes and the separation gel. They contain growth factors which affect conjunctive, osseous and epithelial tissues and initiate their regeneration also they stimulate the formation and activation of fibroblasts producing collagen, hyaluronic acid and elastin, synthesizing a young tissue that normalizes tissue respiration and balances metabolic processes.  Results. At the end of the study with the two groups of patients, we determined the reduction of the papillary bleeding index (SBI) after the complex treatment of platelet-rich-plasma (PRP) by MeaPlasma method, for the patients who have been treated with an implant treatment and for patients with diseases of periodontal tissues.  Conclusions. Activating all components of natural regeneration processes, platelet-rich plasma represents a convenient and safe biological remedy that accelerates regenerative processes and for improvement of hygienic and periodontal indices, reduction of gingival bleeding, edema, reduction of dental mobility, normalization of gingival shape and color.