Introduction. Diabetic foot (DF) is one of the most serious consequences of diabetes mellitus that can occur during lifetime in these patients. The burden of DF is very high nowadays and is expected to increase more in the future. The incidence of DF is still rising due to the high prevalence of predisposing factors. Most of the DF amputations are preceded by foot ulceration. Diabetic peripheral neuropathy (DPN) is a major risk factor for foot ulceration. DPN leads to loss of protective sensation resulting in continuous unconscious traumas. Patient education and detection of “high risk foot” are essential for the prevention of foot ulceration and amputation. Management is based on revascularization procedures, wound debridement, treatment of infection and ulcer offloading.Aim of the study. The complex evaluation of patients with DF including clinical differentiation of the neurophatic and neuroischaemic forms, monitoring of the disease evolution and development of complications as well as determination of the optimal non-surgical and surgical treatment. Materials and methods. The retrospective study has been performed in the General Surgery Department of the Republican Clinical Hospital “Timofei Mosneaga” (Chisinau) during the year 2017. The study group included 99 patients with complicated diabetes mellitus. The clinical data of the patients was collected from their medical records. Results. According to the study 62% of the patients were male and 38% female, the majority in the age between 61 and 70 years. Most of patients have suffered diabetes mellitus type II (96%). In 78% of patients neuroischaemic form of DF was diagnosed and only in 22% - neuropathic form. Complications occurred in patients who have diabetes mellitus for at least 5 years. Most of the patients suffered with grade III or IV DF, according to the Wagner classification. Surgical treatment included the following procedures: necrectomy, amputations, opening and draining of the phlegmon, percutaneous transluminal angioplasty. Conclusion. DF ulceration is generally preventable. The first step in ulcer prevention is the careful screening for foot problems and detection of patients at high risk. More research is still required to improve the diagnosis of conditions leading to foot ulceration. Multi-disciplinary team approach is required to effectively manage the different aspects of DF syndrome.