Sewage sludge (SS) is a secondary resource that can be used in modern biotechnology to produce fertilizers. This is the bioconversion of organic waste – obtaining available organic raw materials (compost) with the participation of phosphate-mobilizing microorganisms with the addition of fillers. Biofertilizers based on SS of biological treatment plants (SBU) "Southern" and "Northern" of Odessa with different fillers (winter wheat straw and sunflower seed husk) were studied. The effectiveness of biofertilizers was studied in a field experiment on chernozem ordinary medium humus. Culture in the experiment: corn for grain (medium-ripe hybrid FAO 400). According to the results of determining the biological activity of the soil, the highest indicators of corn yield are shown when using new biofertilizers in comparison with the control, which provided an increase in corn yield per grain and improved economic performance.