Articolul precedent |
Articolul urmator |
719 0 |
SM ISO690:2012 MORĂRESCU (CHETRARU), Olga, GRINCO, Marina, LUNGANU, Maria, UNGUR, Nikon. Obtaining of polyfunctional compounds from the ent-kaur-16-en-19-oic acid using the Prevost – Woodward reaction approach. In: The International Conference dedicated to the 55th anniversary from the foundation of the Institute of Chemistry of the Academy of Sciences of Moldova, 28-30 mai 2014, Chișinău. Chișinău, Republica Moldova: Institutul de Chimie al AȘM, 2014, p. 210. |
EXPORT metadate: Google Scholar Crossref CERIF DataCite Dublin Core |
The International Conference dedicated to the 55th anniversary from the foundation of the Institute of Chemistry of the Academy of Sciences of Moldova 2014 | ||||||
Conferința "The International Conference dedicated to the 55th anniversary from the foundation of the Institute of Chemistry of the Academy of Sciences of Moldova" Chișinău, Moldova, 28-30 mai 2014 | ||||||
|
||||||
Pag. 210-210 | ||||||
|
||||||
Descarcă PDF | ||||||
Rezumat | ||||||
The scientific interest in diterpenic tetracyclic ent-kaur-16-en-19-oic (1) is explained by As a result of Prevost–Woodward reaction of ent-kaur-16-en-19-oic acid (1), new |
||||||
|
DataCite XML Export
<?xml version='1.0' encoding='utf-8'?> <resource xmlns:xsi='http://www.w3.org/2001/XMLSchema-instance' xmlns='http://datacite.org/schema/kernel-3' xsi:schemaLocation='http://datacite.org/schema/kernel-3 http://schema.datacite.org/meta/kernel-3/metadata.xsd'> <creators> <creator> <creatorName>Morărescu (Chetraru), O.</creatorName> <affiliation>Institutul de Chimie al AŞM, Moldova, Republica</affiliation> </creator> <creator> <creatorName>Grinco, M.C.</creatorName> <affiliation>Institutul de Chimie al AŞM, Moldova, Republica</affiliation> </creator> <creator> <creatorName>Lunganu, M.I.</creatorName> <affiliation>Institutul de Chimie al AŞM, Moldova, Republica</affiliation> </creator> <creator> <creatorName>Ungur, N.D.</creatorName> <affiliation>Institutul de Chimie al AŞM, Moldova, Republica</affiliation> </creator> </creators> <titles> <title xml:lang='en'>Obtaining of polyfunctional compounds from the ent-kaur-16-en-19-oic acid using the Prevost – Woodward reaction approach</title> </titles> <publisher>Instrumentul Bibliometric National</publisher> <publicationYear>2014</publicationYear> <relatedIdentifier relatedIdentifierType='ISBN' relationType='IsPartOf'></relatedIdentifier> <dates> <date dateType='Issued'>2014</date> </dates> <resourceType resourceTypeGeneral='Text'>Conference Paper</resourceType> <descriptions> <description xml:lang='en' descriptionType='Abstract'><p>The scientific interest in diterpenic tetracyclic ent-kaur-16-en-19-oic (1) is explained by<br />the fact that this compound possesses a broad spectrum of biological activities [1-3]. It was<br />isolated from different vegetal sources, especially from sunflower Helianthus sp. [4].<br />Polyfunctionalized tetracyclic ent-kaurenic terpenoids are also of a great interest, as a<br />result of their pronounced biological activity. For the functionalization of ent-kaur-16-en-19-oic<br />acid (1) the Prevost – Woodward method was used.<br />Herein, we present the results of the transformation of ent-kaur-16-en-19-oic acid (1) by<br />reaction with PhI(OAc)2/LiBr, using the method described in the literature [5].<br />As a result, a mixture of diterpenic compounds was obtained, which was purified by<br />column chromatography, resulting in the isolation of the functionalized ent-kaurenic diterpenoids<br />(2) – (4). Their structures were elucidated by 1H, 13C NMR, IR and MS spectroscopies data. It<br />should be mentioned, that diterpenoids (2) - (3) containing a bromine atom at C-17 can<br />potentially be endowed with interesting biological properties.</p><p>As a result of Prevost–Woodward reaction of ent-kaur-16-en-19-oic acid (1), new<br />derivatives of ent-kaurenic acid, functionalized at C-15, C-16 and C-17 carbon atoms, have been<br />obtained.<br />References:<br />1. Na, M. K.; Oh, W, K.; Kim, Y. H.; Cai, X. F.; Kim, S. H.; Kim, B. Y.; Ahn, J. S. Bioorg. Med.<br />Chem. Lett., 2006, 16, 3061–3064.<br />2. Dang, N. H.; Zhang, X. F.; Zheng, M. S.; Son, K. H.; Chang, N. W.; Kim, H. P.; Bae, K. H.;<br />Kang, S. S. Arch. Pharm. Res., 2005, 28, 28-33.<br />3. Jung, H. A.; Lee, E. J.; Kim, J. S.; Kang, S. S.; Lee, J.-H.; Min, B.-S.; Choi, J. S. Arch. Pharm.<br />Res., 2009, 32, 1399-1408.<br />4. Ungur, N.; Grinco, M.; Kulciţki, V.; Barba, A.; Bîzîcci, T.; Vlad, P. F. Chem. J. Mold. 2008, 4<br />(2), 106-109.<br />5. Emmanuvel, L.; Ali Shaikh, T. M.; Sudalai, A. Org. Lett., 2005, 7 (22), 5071-5074.</p></description> </descriptions> <formats> <format>application/pdf</format> </formats> </resource>