The effectiveness of bio rational has developed into (natural chemical fungicides based on copper and sulfur, microbiological prenparaty Rizoplan, Trichoderma, insekto-acaricide Pelekol, plant growth stimulants Alba, Rekola, Pelekol Reglalg synthetic spolovye pheromones, etc.) In the integrated protection of fruit stone fruit orchards studied in a central area of Moldova in comparison with the chemical standard. The biological efficacy of fungicides bio ratsional reached 63.3%, and mass trapping of male apple, plum and eastern moth on pheromone traps 77,0- 86.6%. Elicitors stimulate the growth of fruits and processes of formation of double and triple buds by 7.7% and 19.2%. Application bio rational means reducing of energy and financial costs to protect apple trees by 30-40%.