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SM ISO690:2012 GUŢU, Tatiana, BARBA, Alic, PRISACARU, Viorel. Synthesis of some N’-n-dimethylphenyl-N,N-dimethylthioureas with antiproliferative properties. In: Physical Methods in Coordination and Supramolecular Chemistry, 8-9 octombrie 2015, Chişinău. Chisinau, Republic of Moldova: 2015, XVIII, p. 76. |
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Physical Methods in Coordination and Supramolecular Chemistry XVIII, 2015 |
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Conferința ""Physical Methods in Coordination and Supramolecular Chemistry"" Chişinău, Moldova, 8-9 octombrie 2015 | ||||||
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Pag. 76-76 | ||||||
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Methods for synthesis of newcompounds of thioureeaderivatives are described. Thesecompounds are of both theoretically and practically interest through heir aplications in various fields, as they posses valuable biological activit ysuch as antifungal, antitumour, antiviral, antibacterial, pharmacological, herbicidal, and insecticidal properties. Thioureas have suitable C=S function groups, and they can be considered as useful chelating agents due to their ability to encapsulate into their coordinating moiety metal ions[1].schemeAn efficient method for the synthesis of unsymmetrical substituted thiourea derivatives by means of simple condensation between available building blocks such as amines and carbon disulfide in aqueous medium, but this method uses a toxic reactive as carbon disulfide so we tried to substituteit with the accessible and nontoxic reactive as tetramethyldithiocarbamate (DTMT). Synthesis ofN1-n-dimethylphenyl-N, N- dimethylthioureas was carried between ndimethylaniline and (DTMT). The ends of the reactions were checked by thin layer chromatography (TLC). N1-n-dimethylphenyl-N, N-dimethylthioureas presents white crystalline products, their structure was confirmed by 1H and 13C NMR Spectra and are presented in table below:tableThese compounds were tested as anti proliferative agents. |
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