Seed potato production in a second crop is one of the method to reduce the pressure of viruses and ecological degeneration, and keep longer the seed in good physiological condition and free of virus diseases. Not all the variety are good for second crop. To obtain the good results, high yield with less cost, with new or old tubers the varieties choice should be done in concordance with zone and method of cultivation. For rapid and qualitative dormancy breaking the best solution is to use the combination gibberellic acid, thio-urea, succinic acid, potassium thiocyanate. In the researches was demonstrated that the optimal time of planting in the second crop should be established for each variety or group of variety respecting the date of first frost in air in to the zone of potato production, length of vegetable period, length of the planting- earth up period. Quality of the seed obtained in second crop are higher that quality of the seed from first crop.