Pest management approach is oriented for development to minimize environmental impact. For that reason, there is a necessity to progress biopesticides, which are efficient, ecofriendly and do not consent any destructive consequence. The biopesticides are associated with biological control by implication of living organisms, but now are extended by certain types of pesticides derived from such natural materials from animals, plants, and certain minerals. The aplication of biopesticides, as alternative management products against crop pests, is increasing. There are 299 registered biopesticide active ingredients and 1401 active biopesticide product registrations. The Global biopesticides market is increasing and was worth approximately $3.36 billion in 2016 and is projected to reach $8.82 billion by 2022, at an annual growth rate of 17.4%. The article aimed to present the problems of plant protection and soil fertilityin ecological agriculture, using the possibilities to combat harmful organisms and improving environmental conditions for biological plant protection and sustainable management of fertility in organic farming systems.