It is known that the development of resistant pathogens to a range of antibiotics, has become a major problem of modern medicine [1,2]. In this context an important role has the polymer chemistry with specific functionality regarding the protection from bacteria/fungus and other microorganisms. In this context it was performed the synthesis of Styrene copolymers (ST): butyl methacrylate (BMA): methacrylic acid (ACM). The copolymerization was accomplished by the method of radical polymerization at a temperature of 800C for 4 hours. Conversion of the copolymers ST: BMA ACM with izofural was carried out in dimethylformamide at a temperature of 00C with ethyl chloroformate for 3 hours with an ACM containing from 10 to 30 mol% according to the scheme: H3C COOH H3C O C4H9 O m n L +L Cl-CO2-C2H5 -L HCl (HCl+R3N --> R3N + H] - Cl) t=0 0 C + L HN - izofural - CO2 - C2H5OH H3C H3C O C4H9 O O O O CH3 O m n L H3C H3C O C4H9 O N - izofural O m n L The product obtained in solution was separated and purified two times in diethyl ether. The structure of support polymer ST: BMA: ACM as well as of medical polymer structure was confirmed by IR spectroscopy and elemental analysis. The study of the antimicrobial activity was performed using the reference culture Staphylococcus aureus, Enterococcus faecalis, Escherichia coli, Pseudomonas aeruginosa, Proteus vulgaris. Antimicrobial tests of the copolymers showed activity against these strains significant.Conclusions: 1. It was carried out the synthesis of styrene copolymer: butyl methacrilat methacrylic acid. By polymer-analogous transformation was successful coupling of antimicrobial compounds as izofuralul the copolymer ST: BMA ACM. Copolymer matrix structure and medicinal as was confirmed by IR spectroscopy. 2. The antimicrobial tests have demonstrated activity against copolymers Gram-and Gram+. 3. Mechanical characteristics showed that medicinal polymers can be recommended for medicinal use fabricate objects.