Scientific studies have established that ecological changes of the ecosystems related to the presence of top predators such as wolves, can restore the balance in wilderness areas where the presence of characteristic trophic sources (large ungulates) are abundant, increasing their stability and biological diversity. In the conditions of Moldova the return of the wolf in 2000s in anthropized ecosystems on the background of a number of wild ungulates far below optimal limits brought to the decreasing of this number, particularly in places of their concentration, with quite strong impact on the farms. The wolf survey in the last years shows that the wolf population in Moldova can be assessed at about 80-90 specimens and is at the phase of structuring and accommodation toward trophic and shelter conditions with the formation of reproductive nuclei in the central zone (Vașcăuți-Susleni-Tribugeni with the center in forest stand Țaganca; Barnova–Seseni-Isacova; Petrosu–Măgurele-Bursuceni; Cărbuna-RezeniPuhoi; Văsieni–Costești-Sociteni; Strășeni-Sadova-Micleușeni; Garbăvăț-CopancaCăușăni and on left bank of Nistru River in Carmanovo-Colosovo) and in the southern zone (Tomai-Cneazevca-Beștemac; Beșgioz-Tvardița-Djoltai; Taraclia-Carbalia) (fig. 1), dislocated mostly outside forest stands at ecotone areas of agrocenoses. In parallel there were observed the expansion of jackal hounds occurred in the south of the country in the early 2000s, which are increasingly common in Nistru and Prut floodplain area (about 9-10 groups with a number of over 120 jackals). Given the territorial needs of the wolf - no more than two wolves in 10 thousand ha, and to satisfy the correlation of 1:150 between predator and prey for ecological equilibrium conditions, including trophic requirements, it would be need to have 300 deer and wild boar on the republic territory. In central Codri area on about 100 thousand ha around 40 wolves inhabit, forming 6-8 reproductive hounds, thus having a density of four wolves per 10 000 ha. Also, we must acknowledge that the concentration of wolf hounds is observed in areas with a high density of deer, where the wolves’ density is much higher. At the same time, here there were estimated about 240 deer, 2200 roe deers and nearly 500 wild boar, ensuring only half of wolf trophic needs. Thus, it is forced to attack sheepfolds and cattle left without supervising at grazing, as was noticed in spring of this year (2016) near Bardar, Getlova, Susleni, Sociteni, Costești, Căușeni, Harbovăț villages. Sometimes, the wolf also hunts small animals (hares and even domestic birds near localities). Because in these conditions the wolf is not provided with specific trophic sources, in the vegetation period and often in winter the wolves can hunt in small reproductive groups  (2-3 individuals), often frequenting the places of storage of meat processing industry waste. This type of adaptive structuring of population, determined by the trophic specificity in anthropic conditions favor a higher percentage of reproductive females and finally a numeric jump of wolf population, which under current conditions is an important factor in annual increase of deer populations that at present became the main trophic object in forest ecosystems as well as in agrocoenoses (along with the reestablishment of “field” ecotype). The main problem is not the damages caused to farms by attacking unprotected animals, but it is in the deacrease of the hunting fauna number and primarily ungulates. Figure 1. Distribution of wolf ( ) and jackal ( ) hounds recorded on the territory of Moldova in the period march 2013 - may 2016 In order to return to a balance in relations between wolves and fauna of ungulates there are required studies on localization of wolves’ hounds, assessment of reproductive process and of mechanisms regulating this process in accordance with the distribution and number of prey species. The mechanism of coexistence of predators in anthropized ecosystems requires the implementation of a strategy to prevent the damage at national level and of compensation systems of damage caused by predators protected by national and international laws in line with the appropriate management of these species. The work was performed within the fundamental project 15.187.0211F.