The European Union is, no doubt, at a major political crossroad. Inequalities among its regions and member states are still alarmingly high, despite the considerable efforts made through cohesion policy to reduce them; the immigration crisis amplifies these inequalities, also generating major political outcomes, like Great Britain’s decision to renounce its EU membership. This article offers a general perspective over the European project starting from the premise that the EU’s growing economic coherence is not doubled by the same level of political coherence. The future of the EU itself depends on elaborating, as quickly as possible, a much needed political form and thus making it able to tackle more successfully the whole set of challenges that lies ahead.