Controlling directed protein interaction networks, an overview
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Ultima descărcare din IBN:
2023-05-22 16:29
SM ISO690:2012
ROGOJIN, Vladimir, KANHAIYA, Krishna, CHIU, Wu Kai, GRATIE, Christian, KAZEMI, Keivan, CZEIZLER, Eugen, PETRE, Ion. Controlling directed protein interaction networks, an overview. In: Conference on Mathematical Foundations of Informatics, Ed. 2017, 9-11 noiembrie 2017, Chișinău. Chișinău, Republica Moldova: "VALINEX" SRL, 2017, pp. 150-156. ISBN 978‐9975‐4237‐6‐2.
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Conference on Mathematical Foundations of Informatics 2017
Conferința "Conference on Mathematical Foundations of Informatics"
2017, Chișinău, Moldova, 9-11 noiembrie 2017

Controlling directed protein interaction networks, an overview


Pag. 150-156

Rogojin Vladimir, Kanhaiya Krishna, Chiu Wu Kai, Gratie Christian, Kazemi Keivan, Czeizler Eugen, Petre Ion
 
Abo Akademi University, Turku, Finland
 
Disponibil în IBN: 20 martie 2018


Rezumat

Network controllability research aims at discovering sets of external interventions that can drive a biological system to a targeted state. From the practical point of view, this means finding a (minimal) set of drugs that in combination are able induce a desired response from a cell. Hereby, network controllability may lead to the development of novel therapeutic approaches for systemic diseases like cancer. We summarize here our recent results related to this research direction. In particular, we overview the algorithm of structured network controllability, its implementation as a web application and a number of case studies.  

Cuvinte-cheie
network controllability, software pipeline, protein interaction networks, multi-drug therapy,

Web service, bioinformatics