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SM ISO690:2012 ROGOJIN, Vladimir, KANHAIYA, Krishna, CHIU, Wu Kai, GRATIE, Christian, KAZEMI, Keivan, CZEIZLER, Eugen, PETRE, Ion. Controlling directed protein interaction networks, an overview. In: Conference on Mathematical Foundations of Informatics, Ed. 2017, 9-11 noiembrie 2017, Chișinău. Chișinău, Republica Moldova: "VALINEX" SRL, 2017, pp. 150-156. ISBN 978‐9975‐4237‐6‐2. |
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Conference on Mathematical Foundations of Informatics 2017 | ||||||
Conferința "Conference on Mathematical Foundations of Informatics" 2017, Chișinău, Moldova, 9-11 noiembrie 2017 | ||||||
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Pag. 150-156 | ||||||
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Network controllability research aims at discovering sets of external interventions that can drive a biological system to a targeted state. From the practical point of view, this means finding a (minimal) set of drugs that in combination are able induce a desired response from a cell. Hereby, network controllability may lead to the development of novel therapeutic approaches for systemic diseases like cancer. We summarize here our recent results related to this research direction. In particular, we overview the algorithm of structured network controllability, its implementation as a web application and a number of case studies. |
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Cuvinte-cheie network controllability, software pipeline, protein interaction networks, multi-drug therapy, Web service, bioinformatics |
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<meta name="citation_title" content="Controlling directed protein interaction networks, an overview"> <meta name="citation_author" content="Rogojin Vladimir"> <meta name="citation_author" content="Kanhaiya Krishna"> <meta name="citation_author" content="Chiu Wu Kai"> <meta name="citation_author" content="Gratie Christian"> <meta name="citation_author" content="Kazemi Keivan"> <meta name="citation_author" content="Czeizler Eugen"> <meta name="citation_author" content="Petre Ion"> <meta name="citation_publication_date" content="2017"> <meta name="citation_collection_title" content="Conference on Mathematical Foundations of Informatics"> <meta name="citation_firstpage" content="150"> <meta name="citation_lastpage" content="156"> <meta name="citation_pdf_url" content="https://ibn.idsi.md/sites/default/files/imag_file/150-156.pdf">