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<cfResPubl>
<cfResPublId>ibn-ResPubl-50722</cfResPublId>
<cfResPublDate>2017-02-22</cfResPublDate>
<cfVol>60</cfVol>
<cfIssue>1</cfIssue>
<cfStartPage>15</cfStartPage>
<cfISSN>2537-6373</cfISSN>
<cfURI>https://ibn.idsi.md/ro/vizualizare_articol/50722</cfURI>
<cfTitle cfLangCode='EN' cfTrans='o'>Homocysteine and recurrent miscarriage</cfTitle>
<cfKeyw cfLangCode='EN' cfTrans='o'>homocysteine; spontaneous abortion; recurrent abortion; vitamin B supplementation</cfKeyw>
<cfAbstr cfLangCode='EN' cfTrans='o'>Background: It is known that etiological structure of recurrent miscarriage has genetic, anatomical, infectious and immunological factors; however, the cause of recurrent miscarriage in 50-60% of cases is not completely clear. Homocysteine is a sulfur-containing intermediate product in the normal metabolism of methionine. Development mechanisms of vascular complications of hyperhomocysteinemia are currently being intensively studied. Hyperhomocysteinemia affects a number of mechanisms involved in thrombogenesis including coagulation cascade, vessel-thrombocytic section, oxidation-reduction reactions, endothelium, and vascular smooth muscle cells and is associated with an increased risk of adverse outcomes in pregnancy. Materials and methods: The study included 50 women who had experienced the loss of at least two consecutive pregnancies. The level of the total serum homocysteine was measured via the chemiluminescent method. Results: We found that plasma homocysteine concentration < 10 μmol/l was found in 16 patients (32,0%, 95% CI 19,07 – 44,93), 9 patients (18.0%, 95% CI 7,36 – 28,64) had a fasting plasma homocysteine between 10 μmol/l to 12 μmol/l and 25 patients (50.0%, 95%CI 36,15 – 63,85) had significantly high total serum homocysteine values. Among them, 23 patients (46.0%, 95%CI 32,19 – 59,81) had the concentration between 12 – 30 μmol/l and 2 patients (4,0%, 95%CI -1,43 – 9,43) had the concentration > 30μmol/l. The complex of B vitamin supplementation was recommended at least 2 to 3 months before conception. In the current study, 40 women (80.0%, 95% CI 68,92 – 91,08) have become pregnant, passed the critical periods for pregnancy loss and continued the folate intake during the pregnancy. Conclusions: The prevalence of hyperhomocysteinemia was more in unexplained primary early recurrent miscarriages. The complex of B vitamin supplementation was recommended at least 2 to 3 months before conception and 40 women (80.0%, 95% CI 68,92 – 91,08) became pregnant, passed the critical periods for pregnancy loss and continued the folate intake during the pregnancy. </cfAbstr>
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<cfStartDate>2017-02-22T24:00:00</cfStartDate>
<cfFamilyNames>Visternicean</cfFamilyNames>
<cfFirstNames>Elena</cfFirstNames>
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