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575.1:616.12(478) (1) |
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SM ISO690:2012 CAPROŞ, Natalia, BARBACAR, Nicolae, ISTRATI, Valeriu, POPESCU, Victor, BUTOVSCAIA, Cristina. Genetic factors that predispose to coronary artery disease.. In: Buletinul Academiei de Ştiinţe a Moldovei. Ştiinţele vieţii, 2015, nr. 2(326), pp. 26-29. ISSN 1857-064X. |
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Buletinul Academiei de Ştiinţe a Moldovei. Ştiinţele vieţii | |
Numărul 2(326) / 2015 / ISSN 1857-064X | |
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CZU: 575.1:616.12(478) | |
Pag. 26-29 | |
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The aim of the study was to evaluate the genetic factors that cause or predispose to coronary artery disease (CAD). The case control study was conducted in 2007-2011 and included 405 patients with coronary artery disease and acute ischemic episodes admitted to the Municipal Clinical Hospital „Sfânta Treime“, Chisinău. Insertion/deletion (I/D) genotypes of angiotensin-converting enzyme (ACE) and A1166C polymorphism of angiotensin II type 1 receptor gene, Asp298Glu (A/G) genotypes of the endothelial nitric oxide synthase (eNOS) and PlA1/2 (A1A2) genotypes of GPIIb/IIIa receptor polymorphisms were identified by amplified polymerase chain reaction and restricted fragment length polymorphism. The authors concluded that the carrier of D/D genotype and D allele in ACE gene, being positively correlated with the risk C/C polymorphic variant of angiotensin II type 1 receptor gene was associated with hypertension and cardiovascular death. A2/A2 genotype of glycoprotein (GP) IIb/IIIa receptor gene was associated with susceptibility to CAD and high frequency of myocardial infarction and dyslipidemia, particularly in smokers. 7 references. |
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Cuvinte-cheie coronary artery, genetic diagnosis, genetic factors. |
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<?xml version='1.0' encoding='utf-8'?> <resource xmlns:xsi='http://www.w3.org/2001/XMLSchema-instance' xmlns='http://datacite.org/schema/kernel-3' xsi:schemaLocation='http://datacite.org/schema/kernel-3 http://schema.datacite.org/meta/kernel-3/metadata.xsd'> <creators> <creator> <creatorName>Caproş, N.A.</creatorName> <affiliation>Universitatea de Stat de Medicină şi Farmacie „Nicolae Testemiţanu“, Moldova, Republica</affiliation> </creator> <creator> <creatorName>Barbacar, N.I.</creatorName> <affiliation>Institutul de Genetică, Fiziologie şi Protecţie a Plantelor al AŞM, Moldova, Republica</affiliation> </creator> <creator> <creatorName>Istrati, V.T.</creatorName> <affiliation>Universitatea de Stat de Medicină şi Farmacie „Nicolae Testemiţanu“, Moldova, Republica</affiliation> </creator> <creator> <creatorName>Popescu, V.V.</creatorName> <affiliation>Universitatea de Stat de Medicină şi Farmacie „Nicolae Testemiţanu“, Moldova, Republica</affiliation> </creator> <creator> <creatorName>Butovscaia, C.V.</creatorName> <affiliation>Universitatea de Stat de Medicină şi Farmacie „Nicolae Testemiţanu“, Moldova, Republica</affiliation> </creator> </creators> <titles> <title xml:lang='en'>Genetic factors that predispose to coronary artery disease.</title> </titles> <publisher>Instrumentul Bibliometric National</publisher> <publicationYear>2015</publicationYear> <relatedIdentifier relatedIdentifierType='ISSN' relationType='IsPartOf'>1857-064X</relatedIdentifier> <subjects> <subject>coronary artery</subject> <subject>genetic diagnosis</subject> <subject>genetic factors.</subject> <subject schemeURI='http://udcdata.info/' subjectScheme='UDC'>575.1:616.12(478)</subject> </subjects> <dates> <date dateType='Issued'>2015-06-30</date> </dates> <resourceType resourceTypeGeneral='Text'>Journal article</resourceType> <descriptions> <description xml:lang='en' descriptionType='Abstract'>The aim of the study was to evaluate the genetic factors that cause or predispose to coronary artery disease (CAD). The case control study was conducted in 2007-2011 and included 405 patients with coronary artery disease and acute ischemic episodes admitted to the Municipal Clinical Hospital „Sfânta Treime“, Chisinău. Insertion/deletion (I/D) genotypes of angiotensin-converting enzyme (ACE) and A1166C polymorphism of angiotensin II type 1 receptor gene, Asp298Glu (A/G) genotypes of the endothelial nitric oxide synthase (eNOS) and PlA1/2 (A1A2) genotypes of GPIIb/IIIa receptor polymorphisms were identified by amplified polymerase chain reaction and restricted fragment length polymorphism. The authors concluded that the carrier of D/D genotype and D allele in ACE gene, being positively correlated with the risk C/C polymorphic variant of angiotensin II type 1 receptor gene was associated with hypertension and cardiovascular death. A2/A2 genotype of glycoprotein (GP) IIb/IIIa receptor gene was associated with susceptibility to CAD and high frequency of myocardial infarction and dyslipidemia, particularly in smokers. 7 references.</description> <description xml:lang='ru' descriptionType='Abstract'>Целью нашего исследования было изучение генетических факторов предрасполагающих к ишемической болезни сердца (ИБС). Нами проведенно исследование типа случай-контроль с 2007 по 2011 в котором было включено 405 пациентов с ишемической болезнью сердца госпитализированных в муниципальной клинической больнице “Святая Троица”, города Кишинева. В качестве предрасполагающих к ИБС генетических маркеров были исследованы с помощью полимеразной цепной реакции I/D генотипы ангиотензин-превращающего фермента (ACE) и A1166C полиморфизм гена ангиотензиновых рецепторов I типа, Asp298Glu (A/G) генотип оксида азота синтазы эндотелия (eNOS) и PLA1/2 (A1A2 ) генотип гена гликопротеиновых IIb/IIIa рецепторов. Авторы пришли к выводу, что носители D/D генотипа ангиотензинпревращаего фермента положительно коррелирует с полиморфной вариантой C/C гена ангиотензиновых рецепторов I типа и с артериальной гипертензией. А2/А2 генотип гликопротеиновых IIb/IIIa рецепторов ассоциировалось с ИБС, инфарктом миокарда и высокой частотой дислипидемии, особенно у курильщиков. Библ.- 7. ,</description> </descriptions> <formats> <format>application/pdf</format> </formats> </resource>