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1015 5 |
Ultima descărcare din IBN: 2020-08-14 13:18 |
SM ISO690:2012 EGOROV, Vladimir, SACARĂ, Victoria, UŞURELU, Natalia, MOŞIN, Veaceslav. HLA complex and reproductive pathology. In: Curierul Medical, 2013, nr. 3(56), pp. 51-56. ISSN 1875-0666. |
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Curierul Medical | ||||||
Numărul 3(56) / 2013 / ISSN 1875-0666 | ||||||
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Pag. 51-56 | ||||||
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The authors have proved that the concentration of soluble HLA antigens of class I and II can play a predictive role in prognosing the pregnancy outcome. In fact, there is a direct correlation between the concentration of soluble HLA antigens of class II and mother’s immune stimulation. The concentration of these antigens increases during the 1st and 2nd trimesters of pregnancy and remains stable since then. The concentration of the Ist class HLA antigens during the first trimester is low, but as the immune suppression increases, the level of antigens of this class also increases. The process of immune suppression is opposed to the immune stimulation which can be a threat for the fetus. In couples with normal fertility there is only one or two identical HLA antigens, while in infertile couples there is identity of three or four HLA antigens or the presence of “similar”ones, that is cross-reacting antigens. A large number of matching antigens leads to the fact that the embryo is not recognized by the immune system as a fetus but as a modified cell of its own organism, which stimulates the immune reaction of the fetus destruction. The further investigation of the role of HLA complex to solve the infertility problem is a perspective direction of scientific researches resulting in improvement of the correction methods for reproductive disorders and the methods of treatment of infertile couples. |
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