The assessment of the climate change impact on livestock sector was made based on projections of changes in temperature received by regionalization of global experiments the most reliable for the Republic of Moldova (RoM) CMIP6 22 GCMs introduced by three Socio-Economic Pathways (SSPs): SSP1-2.6, SSP2-4.5, and SSP5-8.5, and projections of changes in productivity of main cereal crops (winter wheat and grain corn). To assess the livestock production vulnerability to climate change by categories, it was used the empirical-statistical approach, linking fluctuations of livestock production to climate conditions during the 1981-2010 observed time period. Using the multiple regression equations relationship in the livestock production variability by categories with projections of changes in temperature and productivity of main cereal crops, there were calculated the future projections of livestock production changes in the RoM (%/20 years) by 2040, 2060 and 2100, relative to 2000-2019 reference time period.