The aim of this study was to elaborate the protocols of clonal micropropagation of oak belonging to economic species in Republic of Moldova. Depending on the combination and concentration of the hormones in the medium different morphogenetic reactions including the callus formation, the development of stems and leaves, the formation of normal leafy shoots were observed. After elongation the shoots with well-developed leaves were transferred to medium for rooting. Rooted oak plantlets were planted on a substrate consisting of the mixture of peat and sand.