Breast cancer represents a current worldwide threat due to high morbidity, mortality and disability. According to the IARC, in 2020, there were about 2.3 million new cases of breast cancer globally and about 685 000 deaths related to breast cancer, with large geographical variations observed between countries and world regions.[1] Only 1.3% of positive breast cancer patients are detected in the early stages, while 24% in the late stages. As the development of 3D printing technologies is rising, creating new methods and using new materials in the proceeding, they have a promising future in the improvement of understanding, diagnosing and managing breast cancer patients by creating anatomical models of tumors for explanatory and surgical purposes, as well as of compatible and safe breast implants. Aim of the study: 1. Determining of the recent improvements in the 3D printing technologies field; 2. Underlying the role of the 3D printed technologies in breast cancer management; 3. Promoting and implementing new ways of personalized medicine through 3D-printing technologies in oncology field. Materials and methods: a literature review was performed using scientific articles from IARC, NCBI, PubMed, Frontiers, Science Direct, 3D Printing in Medicine databases. Results: This review underlines the main domains and purposes of using the 3D printing technologies in the management of breast cancer patients. A personalized approach in surgical treatment of breast cancer and preoperative planning are essential in a successful and high-efficient medical care. Using images of mammary gland from CT or MRI scanning, processing them via computer software and subsequently 3D printing of the gland and tumour models, allows the detailed explanation of patients’ condition and enhance the safe concerns and quality of medical decision in choosing an appropriate and personalized therapeutic tactic, including pre-operative training of tumour excision and post-surgical rehabilitation.[2] The interactive 3D models of tumours can be used during lectures and practical lessons for medical students, enhancing their knowledge about the tumour process and treatment options. Bioprinting allows the modeling and creation of breast gland implants using hypoallergenic, safe and compatible materials with the formation of patient-specific bio-absorbable matrices (scaffolds). On these scaffolds, different types of stem cells in combination with specific growth factors can be seeded and grown, ensuring the processes of adipose tissue formation and angiogenesis. After the resorption of scaffolds, the injected adipose tissue is kept as the extracellular matrix and minimize the significant volume loss of breast adipose tissue, often seen in the lipofilling technique.[3] Conclusion. The 3D printing technologies have a promising role in the development of personalized medicine of breast cancer patients through educational, research, pre- and post-surgical purposes.