Nosocomial transmission of multidrug-resistant tuberculosis
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KRUDU, V., MERKER, Matthias, LANGE, Christoph G., NOROC, Ecaterina, ROMANCENCO, Elena, CHESOV, Dumitru, GUNTHER, Gunar, NIEMANN, Stefan. Nosocomial transmission of multidrug-resistant tuberculosis. In: International Journal of Tuberculosis and Lung Disease, 2015, vol. 19, pp. 1520-1523. ISSN 1027-3719. DOI: https://doi.org/10.5588/ijtld.15.0327
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International Journal of Tuberculosis and Lung Disease
Volumul 19 / 2015 / ISSN 1027-3719 /ISSNe 1815-7920

Nosocomial transmission of multidrug-resistant tuberculosis

DOI:https://doi.org/10.5588/ijtld.15.0327

Pag. 1520-1523

Krudu V.1, Merker Matthias2, Lange Christoph G.234, Noroc Ecaterina1, Romancenco Elena1, Chesov Dumitru4, Gunther Gunar25, Niemann Stefan2
 
1 Institute of Phtysiopneumology „Chiril Draganiuc”,
2 German Centre for Infection Research (DZIF), Partner Site Hamburg-Luebeck-Borstel-Riems,
3 Karolinska Institutet, Stockholm,
4 ”Nicolae Testemițanu” State University of Medicine and Pharmacy,
5 University of Namibia, School of Medicine, Windhoek
 
 
Disponibil în IBN: 2 iunie 2023


Rezumat

Nosocomial transmission of multidrug-resistant tuberculosis (MDR-TB) was ascertained by 24-locus mycobacterial interspersed repetitive units-variable number of tandem repeats (MIRU-VNTR) and spoligotyping at four hospitals in the Republic of Moldova, a high MDR-TB burden country. Overall, 5.1% of patients with pan-susceptible TB at baseline were identified with MDR-TB during in-patient treatment. In 75% of cases, the MDR-TB strain was genetically distinct from the non-MDR-TB strain at baseline, suggesting a high rate of nosocomial transmission of MDR-TB. The highest proportion (40.3%) of followup MDR-TB isolates was associated with the M. tuberculosis URAL 163-15 strain. 

Cuvinte-cheie
Infection control, MDR-TB, Nosocomial transmission, URAL 163-15