Social integration of people with disabilities is a significant issue, therefore effective interventions to provide improvement of quality of life for people who have some kinds of disabilities are crucial. Specialists from various fields, including those in the field of clothing design, are working on creating products that meet people with disabilities’ needs. These products must be ergonomic, comfortable and provide the necessary psychological comfort. The whole process of designing functional products is very complex, it requires continuous research, using knowledge from various fields for better development of products. This paper addresses the topic of developing adaptive clothing for people with multiple sclerosis in the context of social inclusion and adaptation to new ways of life. All the proposals and ideas are analysed accordingly and different constructive and technological solutions are proposed to customize and adapt the basic clothing.