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| Ultima descărcare din IBN: 2023-06-15 21:27 |
 SM ISO690:2012CIOBANU, Liliana, POPOVICI, Ion, COBEŢ, Valeriu, IVANOV, Victoria, COSTIN, Sava. Evaluarea markerilor inflamaţiei în restenoza intra-stent. In: Curierul Medical, 2012, nr. 5(329), pp. 3-8. ISSN 1875-0666. |
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| Curierul Medical | ||||||
| Numărul 5(329) / 2012 / ISSN 1875-0666 | ||||||
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In-stent restenosis is a serious complication that usually follows 6 months after angioplasty. It is believed to be a manifestation of negative coronary remodeling. In order to focus on the role of inflammation in this phenomenon we determined the circulating levels of the lipoprotein-associated phospholipase A2 (Lp-PA2) and C reactive proteins (CRP), as well as the content of macrophages in the restenosis tissue pattern. We found that the blood Lp-A2 and CRP levels were significantly elevated in first 72 hours after angioplasty, independently of the restenosis hazard. We also discovered that after 3 to 6 months these markers remained boosted only in patients with restenosis, while the markers notably declined in those without restenosis. Elevation in inflammation markers was associated with a significant increase in the macrophage amount in the luminal part of restenosis tissue, an important source of the synthesis of the Lp-A2, a marker of endothelial inflammation and dysfunction. |
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| Cuvinte-cheie in-stent restenosis, inflammation markers |
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Dublin Core Export
<?xml version='1.0' encoding='utf-8'?> <oai_dc:dc xmlns:dc='http://purl.org/dc/elements/1.1/' xmlns:oai_dc='http://www.openarchives.org/OAI/2.0/oai_dc/' xmlns:xsi='http://www.w3.org/2001/XMLSchema-instance' xsi:schemaLocation='http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd'> <dc:creator>Ciobanu, L.</dc:creator> <dc:creator>Popovici, I.M.</dc:creator> <dc:creator>Cobeţ, V.A.</dc:creator> <dc:creator>Ivanov, V.M.</dc:creator> <dc:creator>Costin, S.</dc:creator> <dc:date>2012-11-01</dc:date> <dc:description xml:lang='en'>In-stent restenosis is a serious complication that usually follows 6 months after angioplasty. It is believed to be a manifestation of negative coronary remodeling. In order to focus on the role of inflammation in this phenomenon we determined the circulating levels of the lipoprotein-associated phospholipase A2 (Lp-PA2) and C reactive proteins (CRP), as well as the content of macrophages in the restenosis tissue pattern. We found that the blood Lp-A2 and CRP levels were significantly elevated in first 72 hours after angioplasty, independently of the restenosis hazard. We also discovered that after 3 to 6 months these markers remained boosted only in patients with restenosis, while the markers notably declined in those without restenosis. Elevation in inflammation markers was associated with a significant increase in the macrophage amount in the luminal part of restenosis tissue, an important source of the synthesis of the Lp-A2, a marker of endothelial inflammation and dysfunction.</dc:description> <dc:description xml:lang='ru'>Внутристентовый рестеноз, как проявление негативного коронарного ремоделирования, является серьезным осложнением ангиопластики, развивающемся в основном после 6 мес. С целью выявления роли воспаления определили уровень циркулирующих липопротеин-ассоциированной фосфолипазы А2 (Лп-ФЛА2) и С-РБ, а также содержание макрофагов в ткани рестеноза. Уровень Лп-ФЛА2 и С-РБ в крови был достоверно повышен в первые 72 часа после ангиопластики независимо от риска рестеноза. Через 3 и 6 месяцев, однако, он сохранялся высоким только у пациентов с рестенозом, в то время как при отсутствии рестеноза отмечалось снижение этих маркеров. Увеличение в крови маркеров воспаления сопровождалось многократным ростом числа макрофагов в ткани рестеноза со стороны просвета сосуда, источника синтеза Лп-ФЛА2, маркера воспаления и дисфункции эндотелия.</dc:description> <dc:source>Curierul Medical 329 (5) 3-8</dc:source> <dc:subject>in-stent restenosis</dc:subject> <dc:subject>inflammation markers</dc:subject> <dc:title>Evaluarea markerilor inflamaţiei în restenoza intra-stent</dc:title> <dc:type>info:eu-repo/semantics/article</dc:type> </oai_dc:dc>
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