Evaluarea markerilor inflamaţiei în restenoza intra-stent

Ciobanu Liliana; Popovici Ion; Cobeţ Valeriu; Ivanov Victoria; Costin Sava

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2023-06-15 21:27

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CIOBANU, Liliana, POPOVICI, Ion, COBEŢ, Valeriu, IVANOV, Victoria, COSTIN, Sava. Evaluarea markerilor inflamaţiei în restenoza intra-stent. In: Curierul Medical, 2012, nr. 5(329), pp. 3-8. ISSN 1875-0666.

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Curierul Medical

Numărul 5(329) / 2012 / ISSN 1875-0666

Evaluarea markerilor inflamaţiei în restenoza intra-stent

Pag. 3-8

Ciobanu Liliana¹, Popovici Ion², Cobeţ Valeriu², Ivanov Victoria², Costin Sava²

¹ Universitatea de Stat de Medicină şi Farmacie „Nicolae Testemiţanu“,
² IMSP Institutul de Cardiologie

Disponibil în IBN: 17 decembrie 2013

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In-stent restenosis is a serious complication that usually follows 6 months after angioplasty. It is believed to be a manifestation of negative coronary remodeling. In order to focus on the role of inflammation in this phenomenon we determined the circulating levels of the lipoprotein-associated phospholipase A2 (Lp-PA2) and C reactive proteins (CRP), as well as the content of macrophages in the restenosis tissue pattern. We found that the blood Lp-A2 and CRP levels were significantly elevated in first 72 hours after angioplasty, independently of the restenosis hazard. We also discovered that after 3 to 6 months these markers remained boosted only in patients with restenosis, while the markers notably declined in those without restenosis. Elevation in inflammation markers was associated with a significant increase in the macrophage amount in the luminal part of restenosis tissue, an important source of the synthesis of the Lp-A2, a marker of endothelial inflammation and dysfunction.

Внутристентовый рестеноз, как проявление негативного коронарного ремоделирования, является серьезным осложнением ангиопластики, развивающемся в основном после 6 мес. С целью выявления роли воспаления определили уровень циркулирующих липопротеин-ассоциированной фосфолипазы А2 (Лп-ФЛА2) и С-РБ, а также содержание макрофагов в ткани рестеноза. Уровень Лп-ФЛА2 и С-РБ в крови был достоверно повышен в первые 72 часа после ангиопластики независимо от риска рестеноза. Через 3 и 6 месяцев, однако, он сохранялся высоким только у пациентов с рестенозом, в то время как при отсутствии рестеноза отмечалось снижение этих маркеров. Увеличение в крови маркеров воспаления сопровождалось многократным ростом числа макрофагов в ткани рестеноза со стороны просвета сосуда, источника синтеза Лп-ФЛА2, маркера воспаления и дисфункции эндотелия.

Cuvinte-cheie
in-stent restenosis, inflammation markers

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