Social exclusion in European countries is a real problem. It directly affects human rights, brings high costs to society, and hinders the realization of the human potential of vulnerable groups and sustainable economic growth. There are different forms of exclusion a person: economic, cultural, and social exclusion. In addition, there are many structural reasons for exclusion from society that are unrelated to a person’s personal choice, and there are also different degrees of social exclusion. Economic inequality is primarily related to differences in the income generated through paid employment, social transfers, and other household income. And secondly, there are differences in access to social services (education, healthcare). The main subject of the study is the methodology for assessing social exclusion. The main goal is the analysis of social exclusion indicators and calculation methods in the context of adapting the indicators used in European countries for the Republic of Moldova. General scientific methods were used to achieve the purpose of the research: scientific abstraction, induction, deduction, analysis, synthesis, positive and normative analysis, and comparative analysis. The most common indicators used in European countries to assess social exclusion are AROPE and Laeken. In the case of the Republic of Moldova, it is necessary to use the AROPE index, and it is rational to use the social inclusion index built based on self-assessments by the population of their protection from various dangers and threats.