The  paper  presents  the  results  of  the  study  of  the  biological  features  and  chemical  composition of the essential oil of new medicinal plants for Moldova – Monarda fistulosa L. and Helichrisum italicum (Roth) Guss. The purpose of the research is to study growing  opportunity these species in the condition of Moldova, which are significantly different from the  regions of natural growing of these species. The genus Helichrisum belongs to the family of Asteraceae and consist up to 500 species, widespread  throughout the world. Helichrisum italicum (Roth)Guss naturally occurs in the Mediterranean areas  and its extracts are used in popular medicine in these region. The plants   of   H.italicum   has    a   great   reputation   in   traditional   medicine   due   to   their antimicrobial, anti-oxidant  antiviral properties. Monarda fistulosa L. grows wild in North America and is known for its anti-septic, anti- fungal  properties. Essential oil from both species was obtained from freshly cut plants collected in the mass  flowering stage. In the environmental conditions of Moldova, a high yield of essential oil  (2,4–3,7%) is typical for Monarda. The main components of essential oil of M.fistulosa L. are timol  (40,0–56,6%) and carvacrol (18,7–46.0%), besides1,4-cineol (4,1–11,9%), p-cimen (3,2–3,8%) and in  small quantities linalool (1,7%), linalilacetat (1,2%). Hydro distillation of H. iitalicum of aerial parts give pale yellow oil with a yield of 0,7%. This   oil  was  characterized  by  the  dominance  of  sesquiterpenes  (over  30%),  Oxigen- containing  monoterpenes (mainly limonene – 5,55%), neril acetat up to 24,0%. According  to  our  obtained  results,  the  chemical  composition  of  the  essential  oil  of  H.italicum grown in Moldova is different from those in other countries. The difference is  characterized by the presence of neril acetat, a-curcumen, Y-cadinen, D-limonen as the majoritarian  constituents and by the small percentage of nerol (0,4%), a-pinen (0,3%) and absence of geranil acetat.