Introduction. Gastrointestinal stromal tumors (GISTs) are the most frequent mesenchymal neoplasias of the gastrointestinal tract, making about 1-3% of all gastrointestinal malignancies. Most GISTs arise in the stomach and small bowel. The aim of the study is to present our experience in the management of patients with GIST related emergencies. Materials and methods. The study was carried out on patients admitted to a surgical unit with an emergency situation from January 2008 till July 2014. Patient’s clinical data, radiological and endoscopic findings, surgical procedures, and complications were collected, reviewed and analyzed. Results. A total of 14 patients, 5 males (35.7%) and 9 females (64.3%), M:F=1:1.8, mean age of 53.6±4.7 years (range from 21 to 73), were admitted with different emergencies of clinically and radiologically suspected GISTs. The tumors were located in the stomach in 64.3% (n=9), in the duodenum – 7.1% (n=1), small intestine – 28.6% cases (n=4). The most frequent presenting symptom was gastrointestinal bleeding in 78.6% cases (n=11). One patient (7.1%) presented with intestinal obstruction (n=1) and 2 patients (14.3%) – with perforation and subsequent interintestinal abscess formation or peritonitis. All 14 patients underwent surgery. Surgical options were: gastric wedge resection (n=4), partial gastrectomy (n=4), total gastrectomy (n=1), duodenal resection with termino-terminal anastomosis (n=1), small bowel resection (n=4). Complete resection with R0 margins was achieved in 100% cases (n=14). All 14 patients (100%) showed positivity for c-KIT (CD117). In 7.1% cases (n=1) recurrent disease developed. Due to high malignant potential a total of 6 (42.9%) patients received adjuvant treatment with imatinib mesylate 400mg/day. Conclusions. Although uncommon, the incidence of GISTs is increasing, especially their emergency presentations. GISTs should be included in the differential diagnosis of surgical emergencies.