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SM ISO690:2012 BUJOR, Dina, BALANUȚA, Ana-Mihaela, HORODIŞTEANU-BANUH, Adela, SAVOSCHIN, Dorina, GRIN, Olesea, REVENCO, Ninel. Pattern of antimicrobial resistance in bacterial pathogens among children under 5 years with acute respiratoty infection. In: Cercetarea în biomedicină și sănătate: calitate, excelență și performanță, Ed. 1, 20-22 octombrie 2021, Chişinău. Chișinău, Republica Moldova: 2021, p. 368. ISBN 978-9975-82-223-7 (PDF).. |
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Cercetarea în biomedicină și sănătate: calitate, excelență și performanță 2021 | ||||||
Conferința "Cercetarea în biomedicină și sănătate: calitate, excelență și performanță" 1, Chişinău, Moldova, 20-22 octombrie 2021 | ||||||
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Background. While acute respiratory tract infections are the leading cause of pediatric mortality and morbidity worldwide, pathogen patterns are changing due to factors such as hygiene, vaccination status, and antibiotic resistance. Objective of the study. To elucidate bacterial etiologic spectrum responsible for causing acute respiratory infections in children under five years and pattern of antimicrobial susceptibility and resistance. Material and Methods. A prospective, descriptive study was carried out within the National project "The impact of immunization on the morbidity and mortality of children with respiratory diseases in the Republic of Moldova"(project code) - 20.80009.8007.08. The nasopharyngeal aspirate technique was performed for the collection of specimens. The statistical processing was performed using Microsoft Excel. Results. So far, 75 children have been included in the study, with a mean age of 18 ± 1.6 months. Bacteriological examination of their isolates of the nasopharyngeal specimen identified S. aureus as a predominant bacterial agent colonizing the nasopharynx in young children (32%), being resistant in 66% to penicillins, in 12% to macrolides, and 20% with a high sensitivity to antibiotics. M. Catarrhaliswas highlighted in 20% of cases, the profile of antimicrobial resistance outlined in 40% of cases resistance to Meropenem. The spectrum of respiratory etiology preventable by vaccination detected S.pneumoniae in 1.33% of cases and H.influenzae in 4%. Bacterial growth was missing in 17 cases. Conclusion. Nowadays is needed an increased and ongoing surveillance of antimicrobial resistance to develop current and customized national guidelines based on etiological evidence and susceptibility spectrum so that therapeutic decisions will become targeted and effective. |
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Cuvinte-cheie antimicrobialresistance, acuterespiratoryinfections, children, rezistenţă antimicrobiană, infecții respiratorii acute, copii |
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