The purpose of this paper is an analysis of the evolution of the health of the population in the Northern Region (NDR), an area shaded in this respect, which is in a demographic decline, with a negative natural increase, the demographic aging of the population, being characterized by a decrease in the birth rate due to the very low fertility rate, an accelerated domestic and international emigration, a high level of mortality (we emphasize that the mortality rate in this region is the highest in the country). According to official data in 2019, among the main causes of death of the population, we can mention those of the respiratory system (62%), tumors (15%), diseases of the digestive system (7%), accidents and trauma (6%). This pessimistic picture from the demographic point of view, represents a complex and serious problem with real long-term negative effects on the regional socio-economic development, from which the state officials must urgently take mitigation and remedial measures.