This paper deals with the biological potential of coordination compounds based on binuclear core [Mo^V₂O₂E₂]²⁺ (E = O or S) coordinated with commercially available ligands such as oxalates (Ox²⁻), L-cysteine (L-cys²⁻), L-histidine (L-his⁻), Iminodiacetate (IDA²⁻), Nitrilotriacetate (HNTA²⁻ or NTA³⁻) or ethylenediamine tetraacetate (EDTA⁴⁻) by means of various in vitro assays in a screening approach. Results suggest that the obtained complexes show weak antibacterial and antifungal properties while not being cytotoxic on cancerous and mammalian cells. In contrast, [Mo₂O₂E₂(L-cys)₂]²⁻ complexes stand out as powerful antioxidant, whereas [Mo₂O₂E₂(EDTA)]²⁻ associating tetraphenylphosphonium counter-cations display strong antibiotic activity. Finally, some complexes have evidenced a positive activity towards the growing of spirulina platensis together with a modification of the proportions of biological components inside the cells. These findings reveal promising bioactivity of the bridged binuclear Mo^(+V) cores inside complexes and encourage further research for new highly active yet non-toxic molecules for biological and biomedical applications.