| Conţinutul numărului revistei |
| Articolul precedent |
| Articolul urmator |
 688 0 |
 SM ISO690:2012MORĂRESCU (CHETRARU), Olga, GRINCO, Marina, KULCIŢKI, Veaceslav, BARBA, Alic, GARBUZ, Olga, GUDUMAK, V., GULYA, Aurelian, UNGUR, Nikon. A straightforward synthesis of natural oxygenated ent-kaurenoic acid derivatives. In: Synthetic Communications, 2021, nr. 1(51), pp. 123-133. ISSN 0039-7911. DOI: https://doi.org/10.1080/00397911.2020.1821225 |
| EXPORT metadate: Google Scholar Crossref CERIF DataCite Dublin Core |
 Synthetic Communications |
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| Numărul 1(51) / 2021 / ISSN 0039-7911 /ISSNe 1532-2432 | ||||||
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| DOI:https://doi.org/10.1080/00397911.2020.1821225 | ||||||
| Pag. 123-133 | ||||||
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The paper presents the synthesis of some natural diterpenoids of ent-kauranic structure, starting from ent-kaur-16-en-19-oic acid, a natural diterpenoid readily available from the dried wastes of sunflower (Helianthus annuus L.). The reported ent-16α,17-dihydroxykauran-19-oic, ent-16α-hydroxy-17-acetoxykauran-19-oic and ent-16α,17-diacetoxykauran-19-oic acids have been previously isolated from different plant sources and showed diverse biological activities, including anti-HIV, anti-cancer and anti-Alzheimer properties. Their chemical synthesis has not been disclosed so far. Additional cytotoxicity studies of the obtained compounds revealed a remarkable cell proliferative effect of parent ent-kaur-16-en-19-oic acid and two of its synthetic derivatives, which is in line with recent pioneering studies in this area. |
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| Cuvinte-cheie Allylic isomerization, bioactivity, cell proliferation, dihydroxilation, ent-16, ent-16α-hydroxy-17-acetoxykauran-19-oic acid, ent-16α17-dihydroxylkauran-19-oic acid, ent-16α17-epoxykauran-19-oic acid, ent-17-hydroxykaur-15-en-19-oic acid, ent-17-oxo-16R-kauran-19-oic acident-kaur-16-en-19-oic acid, ent-kaurane, epoxidation, natural diterpenoids, α17-diacetoxykauran-19-oic acid |
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<meta name="citation_title" content="A straightforward synthesis of natural oxygenated ent-kaurenoic acid derivatives"> <meta name="citation_author" content="Morărescu (Chetraru) Olga"> <meta name="citation_author" content="Grinco Marina"> <meta name="citation_author" content="Kulciţki Veaceslav"> <meta name="citation_author" content="Barba Alic"> <meta name="citation_author" content="Garbuz Olga"> <meta name="citation_author" content="Gudumak V."> <meta name="citation_author" content="Gulya Aurelian"> <meta name="citation_author" content="Ungur Nikon"> <meta name="citation_publication_date" content="2021/01/14"> <meta name="citation_journal_title" content="Synthetic Communications"> <meta name="citation_volume" content="51"> <meta name="citation_issue" content="1"> <meta name="citation_firstpage" content="123"> <meta name="citation_lastpage" content="133"> <meta name="citation_pdf_url" content="https://www.tandfonline.com/doi/abs/10.1080/00397911.2020.1821225">
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